Laser photothermal therapy in treatment of mouse melanoma

Wei R. Chen; Kirill Andrienko; Kenneth E. Bartels; Steven D. Martin; Hong Liu; Robert E. Nordquist

doi:10.1117/12.591994

15 April 2005 Laser photothermal therapy in treatment of mouse melanoma

Wei R. Chen, Kirill Andrienko, Kenneth E. Bartels, Steven D. Martin, Hong Liu, Robert E. Nordquist

Proceedings Volume 5695, Optical Interactions with Tissue and Cells XVI; (2005) https://doi.org/10.1117/12.591994
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Laser photophysical interactions have been used in treatment of cancers. The use of laser energy provides high target selectivity. With photosensitizers and immunoadjuvants, laser treatment can also provide long-term and systemic effects. Photothermal interaction using an 805-nm diode laser was used to treat metastatic melanoma in mice. B16 tumor cells were implanted subcutaneously in mice. When the tumors reached a size of 0.2 to 0.5 cm³, laser energy was applied to the tumors. The temperature increases was measured using temperature probes. In addition, glycated chitosan (GC), an experimental immunoadjuvant, was also used in combination with the laser treatment. Our experimental results showed that the photothermal interaction could reduce the tumor burdens immediately after the treatment. When GC was used, the survival rates were significantly increased. GC was also applied at different time frames in relation to the laser treatment: 24 hours before, at the same time, and 24 hours after. Our results indicated that when GC was applied 24 hours before the laser treatment, the positive responses of the tumor-bearing animals is higher than that of the other groups. It may be due to the fact that the use of GC can facilitate the immunological stimulation and enhance the treatment of laser.

Citation Download Citation

Wei R. Chen, Kirill Andrienko, Kenneth E. Bartels, Steven D. Martin, Hong Liu, and Robert E. Nordquist "Laser photothermal therapy in treatment of mouse melanoma", Proc. SPIE 5695, Optical Interactions with Tissue and Cells XVI, (15 April 2005); https://doi.org/10.1117/12.591994

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