Multimodal adaptive optics for depth-enhanced high-resolution ophthalmic imaging

Daniel X. Hammer; Mircea Mujat; Nicusor V. Iftimia; Niyom Lue; R. Daniel Ferguson

doi:10.1117/12.846583

2 March 2010 Multimodal adaptive optics for depth-enhanced high-resolution ophthalmic imaging

Daniel X. Hammer, Mircea Mujat, Nicusor V. Iftimia, Niyom Lue, R. Daniel Ferguson

Proceedings Volume 7550, Ophthalmic Technologies XX; 755011 (2010) https://doi.org/10.1117/12.846583
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We developed a multimodal adaptive optics (AO) retinal imager for diagnosis of retinal diseases, including glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD), and retinitis pigmentosa (RP). The development represents the first ever high performance AO system constructed that combines AO-corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in a single compact clinical prototype platform. The SSOCT channel operates at a wavelength of 1 μm for increased penetration and visualization of the choriocapillaris and choroid, sites of major disease activity for DR and wet AMD. The system is designed to operate on a broad clinical population with a dual deformable mirror (DM) configuration that allows simultaneous low- and high-order aberration correction. The system also includes a wide field line scanning ophthalmoscope (LSO) for initial screening, target identification, and global orientation; an integrated retinal tracker (RT) to stabilize the SLO, OCT, and LSO imaging fields in the presence of rotational eye motion; and a high-resolution LCD-based fixation target for presentation to the subject of stimuli and other visual cues. The system was tested in a limited number of human subjects without retinal disease for performance optimization and validation. The system was able to resolve and quantify cone photoreceptors across the macula to within ~0.5 deg (~100-150 μm) of the fovea, image and delineate ten retinal layers, and penetrate to resolve targets deep into the choroid. In addition to instrument hardware development, analysis algorithms were developed for efficient information extraction from clinical imaging sessions, with functionality including automated image registration, photoreceptor counting, strip and montage stitching, and segmentation. The system provides clinicians and researchers with high-resolution, high performance adaptive optics imaging to help guide therapies, develop new drugs, and improve patient outcomes.

Citation Download Citation

Daniel X. Hammer, Mircea Mujat, Nicusor V. Iftimia, Niyom Lue, and R. Daniel Ferguson "Multimodal adaptive optics for depth-enhanced high-resolution ophthalmic imaging", Proc. SPIE 7550, Ophthalmic Technologies XX, 755011 (2 March 2010); https://doi.org/10.1117/12.846583

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