Clinically compatible instrumentation for accurate detection of fluorescence intensity and lifetime in turbid media

Ching-Wei Chang; William Lloyd; Robert Wilson; Gregory D. Gillispie; Mary-Ann Mycek

doi:10.1117/12.845789

19 February 2010 Clinically compatible instrumentation for accurate detection of fluorescence intensity and lifetime in turbid media

Ching-Wei Chang, William Lloyd, Robert Wilson, Gregory D. Gillispie, Mary-Ann Mycek

Author Affiliations +

Proceedings Volume 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII; 755503 (2010) https://doi.org/10.1117/12.845789
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We report data collected with a specialized transient digitizer, high repetition rate microchip laser sources, and fiber optic light delivery and collection for rapid remote sensing in tissue-simulating phantoms. The instrumentation is highly suitable for eventual translation to a clinical setting owing to the speed of data acquisition and small footprint. Ranges for data acquisition time and instrument sensitivity were determined by measuring wavelength time matrices (WTMs) from tissue-simulating phantoms. Accuracy of WTM data was validated by comparison with Monte-Carlo simulations of fluorescent light propagation in turbid media.

Citation Download Citation

Ching-Wei Chang, William Lloyd, Robert Wilson, Gregory D. Gillispie, and Mary-Ann Mycek "Clinically compatible instrumentation for accurate detection of fluorescence intensity and lifetime in turbid media", Proc. SPIE 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII, 755503 (19 February 2010); https://doi.org/10.1117/12.845789

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