Functionalized DNA materials for sensing and medical applications

Dwight L. Woolard; James O. Jensen

doi:10.1117/12.884538

13 May 2011 Functionalized DNA materials for sensing and medical applications

Dwight L. Woolard, James O. Jensen

Author Affiliations +

Proceedings Volume 8031, Micro- and Nanotechnology Sensors, Systems, and Applications III; 80310V (2011) https://doi.org/10.1117/12.884538
Event: SPIE Defense, Security, and Sensing, 2011, Orlando, Florida, United States

Abstract

The U.S. Army has strong interests in nanoscale architectures that enable enhanced extraction and controllable multiplication of the THz/IR regime spectral signatures associated with specific bio-molecular targets. Emerging DNAbased nano-assemblies (i.e., either materials or structural devices) will be discussed that realize novel sensing paradigms through the incorporation of organic and/or biological molecules such that they effect highly predictable and controllable changes into the electro-optical properties of the resulting superstructures. Results will be given to illustrate the utility of functionalized DNA materials in biological (and chemical) sensing, and to demonstrate how the basic science can be leveraged to study and develop synthetic antibodies, reporters and vaccines for future medical applications.

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Dwight L. Woolard and James O. Jensen "Functionalized DNA materials for sensing and medical applications", Proc. SPIE 8031, Micro- and Nanotechnology Sensors, Systems, and Applications III, 80310V (13 May 2011); https://doi.org/10.1117/12.884538

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KEYWORDS

Molecules

Receptors

Smart materials

Terahertz radiation

Biosensing

Sensors

Molecular biology

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