Multimodal imaging of ischemic wounds

Shiwu Zhang; Surya Gnyawali; Jiwei Huang; Peng Liu; Gayle Gordillo; Chandan K. Sen; Ronald Xu

doi:10.1117/12.1000018

11 December 2012 Multimodal imaging of ischemic wounds

Shiwu Zhang, Surya Gnyawali, Jiwei Huang, Peng Liu, Gayle Gordillo, Chandan K. Sen, Ronald Xu

Proceedings Volume 8553, Optics in Health Care and Biomedical Optics V; 85531G (2012) https://doi.org/10.1117/12.1000018
Event: Photonics Asia, 2012, Beijing, China

Abstract

The wound healing process involves the reparative phases of inflammation, proliferation, and remodeling. Interrupting any of these phases may result in chronically unhealed wounds, amputation, or even patient death. Quantitative assessment of wound tissue ischemia, perfusion, and inflammation provides critical information for appropriate detection, staging, and treatment of chronic wounds. However, no method is available for noninvasive, simultaneous, and quantitative imaging of these tissue parameters. We integrated hyperspectral, laser speckle, and thermographic imaging modalities into a single setup for multimodal assessment of tissue oxygenation, perfusion, and inflammation characteristics. Advanced algorithms were developed for accurate reconstruction of wound oxygenation and appropriate co-registration between different imaging modalities. The multimodal wound imaging system was validated by an ongoing clinical trials approved by OSU IRB. In the clinical trial, a wound of 3mm in diameter was introduced on a healthy subject’s lower extremity and the healing process was serially monitored by the multimodal imaging setup. Our experiments demonstrated the clinical usability of multimodal wound imaging.

Citation Download Citation

Shiwu Zhang, Surya Gnyawali, Jiwei Huang, Peng Liu, Gayle Gordillo, Chandan K. Sen, and Ronald Xu "Multimodal imaging of ischemic wounds", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85531G (11 December 2012); https://doi.org/10.1117/12.1000018

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