Living tissue imaging using gold nanobipyramid contrast agents and polarization sensitive optical coherence tomography

Pelham Keahey; Peng Si; Martin Villiger; Adam de la Zerda; Brett Bouma

doi:10.1117/12.2612087

7 March 2022 Living tissue imaging using gold nanobipyramid contrast agents and polarization sensitive optical coherence tomography

Pelham Keahey, Peng Si, Martin Villiger, Adam de la Zerda, Brett Bouma

Author Affiliations +

Proceedings Volume PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; PC1194818 (2022) https://doi.org/10.1117/12.2612087
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Polarization Sensitive Optical Coherence Tomography (PS-OCT) measures the intensity and polarization state of backscattered light to provide information about tissue structure, retardation and depolarization. Developing molecular contrast agents for PS-OCT could also provide physiological, cellular, and molecular information. In this study, we utilize the depolarization and spectral signature of anisotropic gold nanobipyramids (GNBPs) and demonstrate how the optical properties of these nanostructures can be used as contrast agents for PS-OCT in living tissue.

Conference Presentation

Citation Download Citation

Pelham Keahey, Peng Si, Martin Villiger, Adam de la Zerda, and Brett Bouma "Living tissue imaging using gold nanobipyramid contrast agents and polarization sensitive optical coherence tomography", Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC1194818 (7 March 2022); https://doi.org/10.1117/12.2612087

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