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7 March 2022 High-speed wide-field functional photoacoustic microscopy of mouse brain actions
Xiaoyi Zhu, Qiang Huang, Anthony DiSpirito, Tri Vu, Qiangzhou Rong, Xiaorui Peng, Huaxin Sheng, Xiling Shen, Qifa Zhou, Laiming Jiang, Ulrike Hoffmann, Junjie Yao
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Proceedings Volume PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022; PC119600Z (2022) https://doi.org/10.1117/12.2608398
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
We present a new functional photoacoustic microscopy system with the highest imaging speed and ultrawide field of view. The high imaging speed is enabled by a 12-facets polygon for fast scanning and a Raman-shifter system for fast dual-wavelength measurement of oxygen saturation in vivo. we imaged the dynamic functions in mouse brains in response to hypoxia challenge, sodium nitroprusside (SNP), and ischemic stroke. The experimental results have demonstrated that the high-speed photoacoustic microscopy system can be a powerful tool for studying the rapid hemodynamics in the mouse brains of a wide range of pathological and physiological models.
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Xiaoyi Zhu, Qiang Huang, Anthony DiSpirito, Tri Vu, Qiangzhou Rong, Xiaorui Peng, Huaxin Sheng, Xiling Shen, Qifa Zhou, Laiming Jiang, Ulrike Hoffmann, and Junjie Yao "High-speed wide-field functional photoacoustic microscopy of mouse brain actions", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119600Z (7 March 2022); https://doi.org/10.1117/12.2608398
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KEYWORDS
Brain
Photoacoustic microscopy
Signal detection
Imaging systems
Neuroimaging
Oxygen
Medical research
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