Triple-input polarization sensitive optical coherence tomography improves the birefringence sensitivity by reconstruction of full Mueller matrix of the sample

Xinyu Liu; Liqin Jiang; Jacqueline Chua; Quan V. Hoang; Bingyao Tan; Valentina Bellemo; Veluchamy A. Barathi; Martin Villiger; Leopold Schmetterer

doi:10.1117/12.2652928

9 March 2023 Triple-input polarization sensitive optical coherence tomography improves the birefringence sensitivity by reconstruction of full Mueller matrix of the sample

Xinyu Liu, Liqin Jiang, Jacqueline Chua, Quan V. Hoang, Bingyao Tan, Valentina Bellemo, Veluchamy A. Barathi, Martin Villiger, Leopold Schmetterer

Author Affiliations +

Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC1236714 (2023) https://doi.org/10.1117/12.2652928
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Polarization-sensitive OCT (PS-OCT) derives image contrast from tissue birefringence. Here, we introduced triple-input polarization sensitive optical coherence tomography (TRIPS-OCT), a new polarimetric modulation and reconstruction strategy for depth-resolved tomographic birefringence imaging in-vivo. We modulated the polarization states between three repeated frames and enabled the reconstruction of the Mueller matrix at each location within the triple-measured frames. We demonstrated a 2-fold reduction of the birefringence noise floor compared to the conventional dual-input reconstruction method, and a 3-fold reduction of the measurement error of optic axis orientation in retinal imaging with the compensation of corneal retardance and diattenuation.

Conference Presentation

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Xinyu Liu, Liqin Jiang, Jacqueline Chua, Quan V. Hoang, Bingyao Tan, Valentina Bellemo, Veluchamy A. Barathi, Martin Villiger, and Leopold Schmetterer "Triple-input polarization sensitive optical coherence tomography improves the birefringence sensitivity by reconstruction of full Mueller matrix of the sample", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC1236714 (9 March 2023); https://doi.org/10.1117/12.2652928

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