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16 March 2023 Fluorescence sensing and intravascular microdialysis for personalised medicine: The case of immunosuppressants in transplanted patients (Conference Presentation)
Francesco Baldini, Sara Tombelli, Cosimo Trono, Simone Berneschi, Ambra Giannetti, Romeo Bernini, Gianluca Persichetti, Genni Testa, Guillermo Orellana, Francesca Salis, Susanne Weber, Peter B. Luppa, Giampiero Porro, Giovanna Quartu, Markus B. Schubert, Marcel Berner, Holger Becker, Claudia Gärtner, Mark T. O'Connell
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Proceedings Volume PC12387, Optical Diagnostics and Sensing XXIII: Toward Point-of-Care Diagnostics; PC123870A (2023) https://doi.org/10.1117/12.2655869
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
A fluorescence-based device was developed for immunosuppressants. A measuring chip with ten parallel microchannels allows the simultaneous detection of more than one analyte with replicate measurements. The device is equipped with a microfluidic circuitry, which handles the sample mixing with necessary chemicals using an additional chip and its pumping into the measuring chip, and with integrated thin-film amorphous silicon photodiodes for the fluorescence detection. Submicrometric fluorescent magnetic particles are used to improve the efficiency of the assay. Results on the measurements of mycophenolic acid and cyclosporine A in both spiked solutions and microdialysate samples from patient blood are reported.
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© (2023) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Francesco Baldini, Sara Tombelli, Cosimo Trono, Simone Berneschi, Ambra Giannetti, Romeo Bernini, Gianluca Persichetti, Genni Testa, Guillermo Orellana, Francesca Salis, Susanne Weber, Peter B. Luppa, Giampiero Porro, Giovanna Quartu, Markus B. Schubert, Marcel Berner, Holger Becker, Claudia Gärtner, and Mark T. O'Connell "Fluorescence sensing and intravascular microdialysis for personalised medicine: The case of immunosuppressants in transplanted patients (Conference Presentation)", Proc. SPIE PC12387, Optical Diagnostics and Sensing XXIII: Toward Point-of-Care Diagnostics, PC123870A (16 March 2023); https://doi.org/10.1117/12.2655869
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KEYWORDS
Medicine
Luminescence
Point-of-care devices
Particles
Pathology
Photodiodes
Thin film devices
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