Newly-recognized mechanisms for a well-known chemotherapeutic agent: Immune-stimulatory effects of 5-fluorouracil enhance PDT treatment of nonmelanoma skin cancers

Sanjay Anand; Cheng-En Cheng; Alan Shen; Jacky Chen; Tayyaba Hasan; Edward V. Maytin

doi:10.1117/12.3021788

13 March 2024 Newly-recognized mechanisms for a well-known chemotherapeutic agent: Immune-stimulatory effects of 5-fluorouracil enhance PDT treatment of nonmelanoma skin cancers

Sanjay Anand, Cheng-En Cheng, Alan Shen, Jacky Chen, Tayyaba Hasan, Edward V. Maytin

Author Affiliations +

Proceedings Volume PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII; PC128230I (2024) https://doi.org/10.1117/12.3021788
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

5-fluorouracil (5FU) and photodynamic therapy (PDT) are two popular cancer therapies that induce long-term anti-tumor immunity, mediated by cells of the innate and adaptive immune systems, in addition to their primary tumor-killing effects. The 5FU pretreatment combination with PDT (cPDT), involving the application of aminolevulinic acid (ALA), accumulation of protoporphyrin IX (PpIX) in tumors, and exposure to blue light results in lesion clearance mainly by immunological cell death. When combined, 5FU and PDT potentiate the generation of anti-tumor immune responses, resulting in a greater tumor reduction than is possible with either treatment modality given alone.

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Sanjay Anand, Cheng-En Cheng, Alan Shen, Jacky Chen, Tayyaba Hasan, and Edward V. Maytin "Newly-recognized mechanisms for a well-known chemotherapeutic agent: Immune-stimulatory effects of 5-fluorouracil enhance PDT treatment of nonmelanoma skin cancers", Proc. SPIE PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, PC128230I (13 March 2024); https://doi.org/10.1117/12.3021788

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