In vivo stiffness measurement of epidermis, dermis, and hypodermis using broadband Rayleigh-wave optical coherence elastography

Xu Feng; Guo-Yang Li; Antoine Ramier; Amira Eltony; Seok-Hyun Yun

doi:10.1117/12.2691018

13 March 2024 In vivo stiffness measurement of epidermis, dermis, and hypodermis using broadband Rayleigh-wave optical coherence elastography

Xu Feng, Guo-Yang Li, Antoine Ramier, Amira Eltony, Seok-Hyun Yun

Author Affiliations +

Proceedings Volume PC12844, Optical Elastography and Tissue Biomechanics XI; PC1284402 (2024) https://doi.org/10.1117/12.2691018
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Quantifying the mechanical properties in thin layered structures poses a challenge due to the limited spatial resolution of the available mechanical analysis tools. Here, we propose a broadband (0.1 – 10 kHz) Rayleigh-wave optical coherence elastography technique and a bilayer-based inverse model to determine the elastic moduli of all three skin layers in vivo with high reliability. Our results show that 4 – 10 kHz, a previously unexplored frequency range, is critical to resolve the thin epidermis. Our proposed method is valuable for depth-resolved mechanical characterization of various layered materials and tissues.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Xu Feng, Guo-Yang Li, Antoine Ramier, Amira Eltony, and Seok-Hyun Yun "In vivo stiffness measurement of epidermis, dermis, and hypodermis using broadband Rayleigh-wave optical coherence elastography", Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC1284402 (13 March 2024); https://doi.org/10.1117/12.2691018

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