Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue

Roberto Reif; Mei Wang; Shailendra Joshi; Ousama M. Aamar; Irving J. Bigio

doi:10.1117/1.2744025

1 May 2007 Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue

Roberto Reif, Mei Wang, Shailendra Joshi, Ousama M. Aamar, Irving J. Bigio

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Journal of Biomedical Optics, Vol. 12, Issue 3, 034036 (May 2007). https://doi.org/10.1117/1.2744025

Abstract

The understanding of drug delivery to organs, such as the brain, has been hampered by the inability to measure tissue drug concentrations in real time. We report an application of an optical spectroscopy technique that monitors in vivo the real-time drug concentrations in small volumes of brain tissue. This method will facilitate development of new protocols for delivery of drugs to treat brain cancers. The delivery of many anticancer drugs to the brain is limited by the presence of the blood-brain barrier (BBB). Mitoxantrone (MTX) is a water-soluble anticancer drug that poorly penetrates the BBB. It is preliminarily determined in an animal model that the brain tissue uptake of chemotherapy agents—in this demonstration, MTX—delivered intra-arterially is enhanced when the BBB is disrupted.

©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Roberto Reif, Mei Wang, Shailendra Joshi, Ousama M. Aamar, and Irving J. Bigio "Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue," Journal of Biomedical Optics 12(3), 034036 (1 May 2007). https://doi.org/10.1117/1.2744025

Published: 1 May 2007

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