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1 September 2007 In vivo dynamic light scattering imaging of blood coagulation
Vyacheslav Kalchenko, Alexander G. Brill, Michael Bayewitch, Ilya Fine, Vladimir P. Zharov, Ekaterina I. Galanzha M.D., Valery Viktorovich Tuchin, Alon Harmelin
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Journal of Biomedical Optics, Vol. 12, Issue 5, 052002 (September 2007). https://doi.org/10.1117/1.2778695
Abstract
Physiological blood coagulation/clotting is an essential biological process that is initiated by vessel injury and includes a cascade of enzymatic reactions finalized by fibrin polymerization and clot formation. We utilize dynamic light scattering (DLS) imaging to monitor in vivo red cell mobility as an indicator of blood coagulation. In the course of the experiments, blood flow is arrested using mechanical occlusion, and then laser injury is applied. We demonstrate that the combination of laser injury with DLS imaging on occluded blood vessels (i.e., under static conditions) is suitable to detect even subtle changes of plasma viscosity in the circulatory system, which reflects the process of clot development. This approach is noninvasive and has a relatively simple and easy-to-use technical design. Thus, the proposed methodology provides a promising tool for investigating blood clotting within the vasculature.
©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Vyacheslav Kalchenko, Alexander G. Brill, Michael Bayewitch, Ilya Fine, Vladimir P. Zharov, Ekaterina I. Galanzha M.D., Valery Viktorovich Tuchin, and Alon Harmelin "In vivo dynamic light scattering imaging of blood coagulation," Journal of Biomedical Optics 12(5), 052002 (1 September 2007). https://doi.org/10.1117/1.2778695
Published: 1 September 2007
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Cited by 27 scholarly publications and 12 patents.
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KEYWORDS
Blood
In vivo imaging
Blood vessels
Ear
Injuries
Dynamic light scattering
Blood circulation
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