Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography

Michael A. Choma M.D.; Melissa J. Suter; Benjamin J. Vakoc; Brett E. Bouma; Gary J. Tearney

doi:10.1117/1.3503418

1 September 2010 Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography

Michael A. Choma M.D., Melissa J. Suter, Benjamin J. Vakoc, Brett E. Bouma, Gary J. Tearney

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Journal of Biomedical Optics, Vol. 15, Issue 5, 056020 (September 2010). https://doi.org/10.1117/1.3503418

Abstract

Drosophila melanogaster (fruit fly) is a central organism in biology and is becoming increasingly important in the cardiovascular sciences. Prior work in optical imaging of the D. melanogaster heart has focused on static and dynamic structural anatomy. In the study, it is demonstrated that Doppler optical coherence tomography can quantify dynamic heart wall velocity and hemolymph flow in adult D. melanogaster. Since hemolymph is optically transparent, a novel exogenous contrast technique is demonstrated to increase the backscatter-based intracardiac Doppler flow signal. The results presented here open up new possibilities for functional cardiovascular phenotyping of normal and mutant D. melanogaster.

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Michael A. Choma M.D., Melissa J. Suter, Benjamin J. Vakoc, Brett E. Bouma, and Gary J. Tearney "Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography," Journal of Biomedical Optics 15(5), 056020 (1 September 2010). https://doi.org/10.1117/1.3503418

Published: 1 September 2010

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