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1 November 2012 Detection of cerebral autoregulation by near-infrared spectroscopy in neonates: performance analysis of measurement methods
Alexander Caicedo, Gunnar Naulaers, Petra Lemmers, Frank van Bel, Martin Wolf, Sabine Van Huffel
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Journal of Biomedical Optics, Vol. 17, Issue 11, 117003 (November 2012). https://doi.org/10.1117/1.JBO.17.11.117003
Abstract
Cerebral Autoregulation, in clinical practice, is assessed by means of correlation or coherence analysis between mean arterial blood pressure (MABP) and cerebral blood flow (CBF). However, even though there is evidence linking cerebral autoregulation assessment with clinical outcome in preterm infants, available methods lack precision for clinical use. Classical methods, used for cerebral autoregulation, are influenced by the choice of parameters such as the length of the epoch under analysis and the choice of suitable frequency bands. The influence of these parameters, in the derived measurements for cerebral autoregulation, has not yet been evaluated. In this study, cerebral autoregulation was assessed using correlation, coherence, a modified version of coherence and transfer function gain, and phase. The influence of the extra-parameters on the final scores was evaluated by means of sensitivity analysis. The methods were applied to a database of 18 neonates with measurements of MABP and tissue oxygenation index (TOI). TOI reflects changes in CBF and was measured by means of near-infrared spectroscopy.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
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Alexander Caicedo, Gunnar Naulaers, Petra Lemmers, Frank van Bel, Martin Wolf, and Sabine Van Huffel "Detection of cerebral autoregulation by near-infrared spectroscopy in neonates: performance analysis of measurement methods," Journal of Biomedical Optics 17(11), 117003 (1 November 2012). https://doi.org/10.1117/1.JBO.17.11.117003
Published: 1 November 2012
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Cited by 24 scholarly publications and 12 patents.
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KEYWORDS
Near infrared spectroscopy
Signal processing
Blood pressure
Interference (communication)
Lithium
Cerebral blood flow
Tissue optics
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