Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

Biwei Yin; Roman V. Kuranov; Austin B. McElroy; S. M. Shams Kazmi; Andrew K. Dunn; Timothy Q. Duong; Thomas E. Milner

doi:10.1117/1.JBO.18.5.056005

2 May 2013 Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

Biwei Yin, Roman V. Kuranov, Austin B. McElroy, S. M. Shams Kazmi, Andrew K. Dunn, Timothy Q. Duong, Thomas E. Milner

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Journal of Biomedical Optics, Vol. 18, Issue 5, 056005 (May 2013). https://doi.org/10.1117/1.JBO.18.5.056005

Abstract

A swept-source dual-wavelength photothermal (DWP) optical coherence tomography (OCT) system is demonstrated for quantitative imaging of microvasculature oxygen saturation. DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitation. A 1,064-nm OCT probe and 770-nm and 800-nm photothermal excitation beams are combined in a single-mode optical fiber to measure microvasculature hemoglobin oxygen saturation (SO₂ ) levels in phantom blood vessels with a range of blood flow speeds (0 to 17 mm/s ). A 50-μm-diameter blood vessel phantom is imaged, and SO₂ levels are measured using DWP-OCT and compared with values provided by a commercial oximeter at various blood oxygen concentrations. The influences of blood flow speed and mechanisms of SNR phase degradation on the accuracy of SO ₂ measurement are identified and investigated.

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Biwei Yin, Roman V. Kuranov, Austin B. McElroy, S. M. Shams Kazmi, Andrew K. Dunn, Timothy Q. Duong, and Thomas E. Milner "Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation," Journal of Biomedical Optics 18(5), 056005 (2 May 2013). https://doi.org/10.1117/1.JBO.18.5.056005

Published: 2 May 2013

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