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31 May 2017 Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing
Emil Sobol, Olga Baum, Anatoly Shekhter, Sebastian Wachsmann-Hogiu, Alexander Shnirelman, Yulia Alexandrovskaya, Ivan Sadovskyy, Valerii Vinokur
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Journal of Biomedical Optics, Vol. 22, Issue 9, 091515 (May 2017). https://doi.org/10.1117/1.JBO.22.9.091515
Abstract
Pores are vital for functioning of avascular tissues. Laser-induced pores play an important role in the process of cartilage regeneration. The aim of any treatment for osteoarthritis is to repair hyaline-type cartilage. The aims of this study are to answer two questions: (1) How do laser-assisted pores affect the cartilaginous cells to synthesize hyaline cartilage (HC)? and (2) How can the size distribution of pores arising in the course of laser radiation be controlled? We have shown that in cartilage, the pores arise predominately near chondrocytes, which promote nutrition of cells and signal molecular transfer that activates regeneration of cartilage. In vivo laser treatment of damaged cartilage of miniature pig joints provides cellular transformation and formation of HC. We propose a simple model of pore formation in biopolymers that paves the way for going beyond the trial-and-error approach when choosing an optimal laser treatment regime. Our findings support the approach toward laser healing of osteoarthritis.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2017/$25.00 © 2017 SPIE
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Emil Sobol, Olga Baum, Anatoly Shekhter, Sebastian Wachsmann-Hogiu, Alexander Shnirelman, Yulia Alexandrovskaya, Ivan Sadovskyy, and Valerii Vinokur "Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing," Journal of Biomedical Optics 22(9), 091515 (31 May 2017). https://doi.org/10.1117/1.JBO.22.9.091515
Received: 29 November 2016; Accepted: 28 April 2017; Published: 31 May 2017
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Cited by 17 scholarly publications and 2 patents.
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KEYWORDS
Cartilage
Laser therapeutics
Biopolymers
In vivo imaging
Tissues
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