Complex regression Doppler optical coherence tomography

Sahar Elahi; Shi Gu; Lars Thrane; Andrew M. Rollins; Michael W. Jenkins

doi:10.1117/1.JBO.23.4.046009

27 April 2018 Complex regression Doppler optical coherence tomography

Sahar Elahi, Shi Gu, Lars Thrane, Andrew M. Rollins, Michael W. Jenkins

Author Affiliations +

Journal of Biomedical Optics, Vol. 23, Issue 4, 046009 (April 2018). https://doi.org/10.1117/1.JBO.23.4.046009

Abstract

We introduce a new method to measure Doppler shifts more accurately and extend the dynamic range of Doppler optical coherence tomography (OCT). The two-point estimate of the conventional Doppler method is replaced with a regression that is applied to high-density B-scans in polar coordinates. We built a high-speed OCT system using a 1.68-MHz Fourier domain mode locked laser to acquire high-density B-scans (16,000 A-lines) at high enough frame rates (∼100 fps) to accurately capture the dynamics of the beating embryonic heart. Flow phantom experiments confirm that the complex regression lowers the minimum detectable velocity from 12.25 mm / s to 374 μm / s, whereas the maximum velocity of 400 mm / s is measured without phase wrapping. Complex regression Doppler OCT also demonstrates higher accuracy and precision compared with the conventional method, particularly when signal-to-noise ratio is low. The extended dynamic range allows monitoring of blood flow over several stages of development in embryos without adjusting the imaging parameters. In addition, applying complex averaging recovers hidden features in structural images.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

Sahar Elahi, Shi Gu, Lars Thrane, Andrew M. Rollins, and Michael W. Jenkins "Complex regression Doppler optical coherence tomography," Journal of Biomedical Optics 23(4), 046009 (27 April 2018). https://doi.org/10.1117/1.JBO.23.4.046009

Received: 12 January 2018; Accepted: 9 April 2018; Published: 27 April 2018

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY