Ms. Angelina A. Savkina Profile

Angelina A. Savkina

at Saratov State Medical Univ.

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Proceedings Article | 29 April 2022 Paper

Laser Doppler flowmetry in assessing the effect of liraglutide on microcirculation in rats with absolute insulin deficiency

Era Popyhova, Tatiana Stepanova, Angelina Savkina, Daria Lagutina, Aleksei Ivanov

Proceedings Volume 12192, 1219207 (2022) https://doi.org/10.1117/12.2624388

KEYWORDS: Blood, Glucose, Skin, Doppler effect, Wavelets, Statistical analysis, Pathogens, Inflammation

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Chronic hyperglycemia is the pathogenetic basis of the occurrence and development of macro- and microvascular disorders in diabetes mellitus (DM). The drug liraglutide is widely used to correct the glycemic profile in diabetic patients. The method of laser Doppler flowmetry (LDF) was used to study microcirculation disorders in rats caused by alloxan diabetes, as well as the state of the microvasculature against the background of hyperglycemia correction with liraglutide. Disturbance of microcirculation (MC) was manifested by a decrease in the perfusion index on the skin of the dorsum of the foot in combination with a decrease in the normalized amplitudes of endothelial and neurogenic fluctuations. In animals that underwent correction of hyperglycemia with liraglutide, stimulation of endotheliumdependent vasodilation and normalization of neurogenic vascular tone of the precapillary link were observed, which contributed to the restoration of impaired microcirculation of the hindpaw skin in rats with alloxan diabetes. Also, liraglutide caused a decrease in the concentration of markers of endothelial dysfunction (ED) in the blood serum and in the level of catecholamines (CA) relative to animals in the comparison group. Liraglutide contributed to the normalization of the serum concentration of vasculoendothelial growth factor (VEGF), the increased level of which indicated the inflammatory activation of endothelial cells.

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