Retinal thickness maps obtained using a scanning laser ophthalmoscope are useful in the diagnosis of macular edema and
other diseases that cause changes in the retinal thickness. However, the thickness measurements are adversely affected
by the presence of blood vessels. This paper studies the effect that the blood vessels have on the computation of the
retinal thickness. The retinal thickness is estimated using maximum-likelihood resolution with anatomical constraints.
The blood vessels are segmented using local image features. Comparison of the retinal thickness with and without the
blood vessel removal is made using correlation coefficient and I-divergence.