Ms. Sing Wei Lau Profile

Sing Wei Lau

at Nanyang Technological Univ

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 5 March 2021 Poster + Presentation + Paper

A study of the effect of microbubbles with different gas cores and saline solution on microbubbles-assisted sonothrombolysis via combined ultrasound and photoacoustic imaging

Dhiman Das, Sing Wei Lau, Manojit Pramanik

Proceedings Volume 11642, 116424H (2021) https://doi.org/10.1117/12.2578048

KEYWORDS: Blood, Ultrasonography, Photoacoustic imaging, Sulfur, Polyurethane, Optical microscopy, Interfaces, Gases, Acoustics

Read Abstract +

Degradation of blood clots using microbubbles and acoustic waves is regarded as microbubbles-assisted sonothrombolysis. This process can be monitored using dual modal clinical ultrasound and photoacoustic imaging. A greater understanding is crucial on how different gas cores of microbubbles and whether the presence of saline in the surfactant solution can affect the stability of microbubbles for sonothrombolysis. In this project, a work on using microbubbles with different gas cores and the effect of saline in the external surfactant solution during microbubbles-assisted sonothrombolysis is reported. To understand the stability of the microbubbles, analysis of the number of microbubbles in surfactant solution was conducted using optical microscopy. Two different gases, sulfur hexafluoride (SF₆) gas and decafluorobutane (C4_F₁₀) gas were used in this study to examine the effects of microbubbles on sonothrombolysis for blood clot removal. Two different bases: deionized (DI) water and saline in the microbubbles’ external surfactant solution were also used in this study to examine the stability of the microbubbles. A high-shear rotor homogenizer was used to synthesize the microbubbles. Porcine blood was used for clot formation in polyurethane tubes. The clot-containing tube was set up and submerged in water tank. It was first subjected to microbubbles treatment and next sonothrombolysis treatment for a total of one hour, with the microbubbles being introduced at the interface of the blood clot simultaneously during the sonothrombolysis treatment. The mass of the treated blood clot was then obtained by weighing it with an analytical balance and the change in mass can be obtained by comparison with the initial mass of blood clot. Percentage change in mass of the blood clot was then calculated and a greater percentage change correlated with a greater sonothrombolysis effect.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years