We propose SPHARM-OT, an enhanced spherical harmonic (SPHARM) surface modeling method using optimal transport (OT) for spherical parameterization. To demonstrate its effectiveness, we apply it to shape analysis of amygdala atrophy in Alzheimer’s disease (AD). Of note, identifying morphological abnormalities of medial temporal structures such as hippocampus and amygdala is an important research topic for early diagnosis of AD. Our empirical study includes two steps: (1) the newly proposed SPHARM-OT method is used to model amygdala shapes of 101 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI); (2) using the random field theory to perform surface-based statistical analysis for detecting shape changes between cognitively normal (CN) and AD participants. We demonstrate that (1) the new SPHARM-OT method could effectively reduce surface mapping distortion and lead to a more accurate shape reconstruction result; and (2) significant shape changes between CN and AD participants are identified on certain amygdalar surface regions.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.