Ms. Yu Sun Profile

Yu Sun

Student at Temple Univ

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Publications (2)

SPIE Journal Paper | 10 September 2022 Open Access

Model-based characterization platform of fiber optic extended-wavelength diffuse reflectance spectroscopy for identification of neurovascular bundles

Yu Sun, Alexander Dumont, Mohammed Shahriar Arefin, Chetan Patil

JBO, Vol. 27, Issue 09, 095002, (September 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.9.095002

KEYWORDS: Tissues, Nerve, Model-based design, Short wave infrared radiation, Optical phantoms, Monte Carlo methods, Fiber optics, Systems modeling, Spectroscopy, Optical properties

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Significance: Fiber-optic extended-wavelength diffuse reflectance spectroscopy (EWDRS) using both visible/near-infrared and shortwave-infrared detectors enables improved detection of spectral absorbances arising from lipids, water, and collagen and has demonstrated promise in a variety of applications, including detection of nerves and neurovascular bundles (NVB). Development of future applications of EWDRS for nerve detection could benefit from the use of model-based analyses including Monte Carlo (MC) simulations and evaluation of agreement between model systems and empirical measurements.Aim: The aim of this work is to characterize agreement between EWDRS measurements and simulations and inform future applications of model-based studies of nerve-detecting applications.Approach: A model-based platform consisting of an ex vivo microsurgical nerve dissection model, unique two-layer optical phantoms, and MC model simulations of fiber-optic EWDRS spectroscopic measurements were used to characterize EWDRS and compare agreement across models. In addition, MC simulations of an EWDRS measurement scenario are performed to provide a representative example of future analyses.Results: EWDRS studies performed in the common chicken thigh femoral nerve microsurgical dissection model indicate similar spectral features for classification of NVB versus adjacent tissues as reported in porcine models and human subjects. A comparison of measurements from unique EWDRS issue mimicking optical phantoms and MC simulations indicates high agreement between the two in homogeneous and two-layer optical phantoms, as well as in dissected tissues. Finally, MC simulations of measurement over a simulated NVB indicate the potential of future applications for measurement of nerve plexus.Conclusions: Characterization of agreement between fiber-optic EWDRS measurements and MC simulations demonstrates strong agreement across a variety of tissues and optical phantoms, offering promise for further use to guide the continued development of EWDRS for translational applications.

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Proceedings Article | 2 March 2022 Presentation + Paper

Characterization of extended-wavelength diffuse reflectance spectroscopy for identification of neurovascular bundles using Monte Carlo models, optical phantoms, and ex vivo animal tissues

Yu Sun, Chetan Patil

Proceedings Volume 11951, 1195105 (2022) https://doi.org/10.1117/12.2609778

KEYWORDS: Tissues, Monte Carlo methods, Animal model studies, Statistical modeling, Optical properties, Optical phantoms, Diffuse reflectance spectroscopy, Near infrared

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