Use of preclinical models alongside clinical tissues to develop a noninvasive multimodal fluorescence detection approach for oral neoplasia detection

Paula Villarreal; Rahul Pal; Xiaoying Yu; Orly Coblens; Suimin Qiu; Rongguang Liang; Xingde Li; Gracie Vargas

doi:10.1117/12.2591126

5 March 2021 Use of preclinical models alongside clinical tissues to develop a noninvasive multimodal fluorescence detection approach for oral neoplasia detection

Paula Villarreal, Rahul Pal, Xiaoying Yu, Orly Coblens, Suimin Qiu, Rongguang Liang, Xingde Li, Gracie Vargas

Author Affiliations +

Proceedings Volume 11633, Design and Quality for Biomedical Technologies XIV; 116330I (2021) https://doi.org/10.1117/12.2591126
Event: SPIE BiOS, 2021, Online Only

Abstract

A study evaluating the use of multimodal widefield fluorescence imaging with nonlinear optical microscopy for detection of oral neoplasia was carried out using human clinical samples alongside a preclinical model with the goal of optimizing the most relevant endpoint measures to facilitate development and translation. Samples (in vivo buccal mucosa and surgical samples of oral cancer) were imaged by WF imaging using filter selection of red and green spectral windows, multispectral WF imaging to obtain WF spectral characteristics, and multiphoton autofluorescence microscopy. Features between preclinical and human samples were compared. Similarities and relevant endpoints for pursuing further development of a multimodal workflow will be discussed.

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Paula Villarreal, Rahul Pal, Xiaoying Yu, Orly Coblens, Suimin Qiu, Rongguang Liang, Xingde Li, and Gracie Vargas "Use of preclinical models alongside clinical tissues to develop a noninvasive multimodal fluorescence detection approach for oral neoplasia detection", Proc. SPIE 11633, Design and Quality for Biomedical Technologies XIV, 116330I (5 March 2021); https://doi.org/10.1117/12.2591126

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