Quantitative assessment of rat corneal thickness and morphology during stem cell therapy by high-speed optical coherence tomography

Cerine Lal; James McGrath; Hrebesh Subhash; Sweta Rani; Thomas Ritter; Martin Leahy

doi:10.1117/12.2212821

21 March 2016 Quantitative assessment of rat corneal thickness and morphology during stem cell therapy by high-speed optical coherence tomography

Cerine Lal, James McGrath, Hrebesh Subhash, Sweta Rani, Thomas Ritter, Martin Leahy

Author Affiliations +

Proceedings Volume 9693, Ophthalmic Technologies XXVI; 96931U (2016) https://doi.org/10.1117/12.2212821
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Optical Coherence Tomography (OCT) is a non-invasive 3 dimensional optical imaging modality that enables high resolution cross sectional imaging in biological tissues and materials. Its high axial and lateral resolution combined with high sensitivity, imaging depth and wide field of view makes it suitable for wide variety of high resolution medical imaging applications at clinically relevant speed. With the advent of swept source lasers, the imaging speed of OCT has increased considerably in recent years. OCT has been used in ophthalmology to study dynamic changes occurring in the cornea and iris, thereby providing physiological and pathological changes that occur within the anterior segment structures such as in glaucoma, during refractive surgery, lamellar keratoplasty and corneal diseases. In this study, we assess the changes in corneal thickness in the anterior segment of the eye during wound healing process in a rat corneal burn model following stem cell therapy using high speed swept source OCT.

Citation Download Citation

Cerine Lal, James McGrath, Hrebesh Subhash, Sweta Rani, Thomas Ritter, and Martin Leahy "Quantitative assessment of rat corneal thickness and morphology during stem cell therapy by high-speed optical coherence tomography", Proc. SPIE 9693, Ophthalmic Technologies XXVI, 96931U (21 March 2016); https://doi.org/10.1117/12.2212821

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