Dr. Hrebesh M. Subhash Profile

Dr. Hrebesh M. Subhash

at Colgate-Palmolive Co

SPIE Involvement:

Author

Area of Expertise:

Medical Devices , Wearable Medical Sensors , Clinical Imaging , Machine Learning & Artificial Intelligence , Optics & Photonics , Signal & Image Processing

Profile Summary

Dr. Hrebesh M. Subhash earned his Ph.D. degree at the School of Engineering division of Yamagata University, Japan. He is presently holding a Senior Technical Associate position with the Colgate-Palmolive Technology Center, Piscataway, New Jersey, USA and work in the field of Clinical imaging and Artificial Intelligence in Biomedical Imaging, specifically digital biomarkers, connected health devices, wearables, biophotonics technologies for resource limited setting clinical applications, image and signal processing. He had authored more than 150 peer reviewed research articles in major scientific journals and conferences. Dr. Hrebesh also contributed 5 book chapters in the field of optical coherence tomography with well known publishers like Springer, CRC press and Wiley-Blackwell etc.

Publications (62)

Proceedings Article | 13 March 2024 Poster + Paper

Poster + Paper

Development and evaluation of a deep learning model for oral soft and hard tissue diagnosis using synthetic image data generated by StyleGAN

Ananya Jana, Vrinda Jain, Abmael Oliveira, Hrebesh Molly Subhash, Dimitris Metaxas

Proceedings Volume 12857, 128570D (2024) https://doi.org/10.1117/12.3000633

KEYWORDS: Teeth, Education and training, Image classification, Data modeling, Image quality, Image analysis, Performance modeling, Tissues, Machine learning, Deep learning

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Proceedings Article | 13 March 2024 Poster + Paper

Poster + Paper

Deep learning framework for connected health and intraoral diagnostics: advancing intraoral soft and hard tissue condition analysis

Vrinda Jain, Ananya Jana, Abmael Oliveira, Thomas Livecchi, Mark Pierce, Hrebesh Subhash

Proceedings Volume 12857, 128570G (2024) https://doi.org/10.1117/12.3001072

KEYWORDS: Teeth, Cameras, RGB color model, Image segmentation, Education and training, Neural networks, Diagnostics, Deep learning, Color, Data modeling

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Proceedings Article | 13 March 2024 Presentation

Presentation

Snapshot polarization imaging for detecting changes in tooth color and demineralization

Thomas Livecchi, Steven Jacques, Hrebesh Subhash, Mark Pierce

Proceedings Volume PC12845, PC1284504 (2024) https://doi.org/10.1117/12.3003129

KEYWORDS: Teeth, Polarization imaging, Cameras, Visualization, Polarization, Linear polarizers, LED lighting, Tissues, RGB color model, Light emitting diodes

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Proceedings Article | 13 March 2024 Presentation

Presentation

Infrared thermography as a novel method for qualitative assessment of human perspiration and sweat pore dynamics

Hrebesh Subhash, Abmael Oliveira, Tochukwu Ofoegbuna, Shyamala Pillai, Mark Pierce

Proceedings Volume PC12841, PC128410H (2024) https://doi.org/10.1117/12.3000811

KEYWORDS: Thermography, Visualization, Body temperature

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Proceedings Article | 13 March 2024 Presentation

Presentation

Volumetric super-resolution imaging of tissues using a confocal pinhole array

Ben Urban, Abmael Oliveira, Thomas Livecchi, Hrebesh Subhash

Proceedings Volume PC12849, PC1284905 (2024) https://doi.org/10.1117/12.3001027

KEYWORDS: Biological imaging, Tissues, Imaging arrays, Super resolution, Molecules, Confocal microscopy, Biological samples, Mirrors, Reconstruction algorithms, Optical microscopy

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Proceedings Article | 13 March 2024 Presentation + Paper

Presentation + Paper

A compact system for multimodal optical tissue analysis via integrated stereo and hyperspectral imaging

Abmael Oliveira, Thomas Livecchi, Steven Jacques, Hrebesh Subhash, Mark Pierce

Proceedings Volume 12827, 1282703 (2024) https://doi.org/10.1117/12.3003338

KEYWORDS: Hyperspectral imaging, Imaging systems, Cameras, Tissues, Calibration, 3D image processing, Biomedical optics, Tissue optics, RGB color model, Light sources and illumination, Multimodal imaging

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Proceedings Article | 13 March 2024 Presentation + Paper

Presentation + Paper

Hyperspectral imaging at visible to near-infrared wavelengths with deep learning to rapidly quantify tissue oxygenation, blood, and melanin content

Thomas Livecchi, Steven Jacques, Hrebesh Subhash, Mark Pierce

Proceedings Volume 12827, 1282704 (2024) https://doi.org/10.1117/12.3003067

KEYWORDS: Artificial neural networks, Tissues, Hyperspectral imaging, Blood, In vivo imaging, Oxygen, Cameras, Diffuse reflectance spectroscopy, Oxygenation, Skin

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Proceedings Article | 13 March 2024 Presentation + Paper

Presentation + Paper

Affordable intraoral camera integrated with deep learning for at-home monitoring and detection of oral soft and hard tissue conditions

Vrinda Jain, Ananya Jana, Abmael Oliveira, Thomas Livecchi, Steven Jacques, Mark Pierce, Hrebesh Subhash

Proceedings Volume 12832, 1283209 (2024) https://doi.org/10.1117/12.3000749

KEYWORDS: Cameras, Education and training, Teeth, Deep learning, Color, Neural networks, Algorithm development, Data modeling, RGB color model, Image processing

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Proceedings Article | 15 March 2023 Poster + Paper

Poster + Paper

Shortwave-infrared spatial frequency domain imaging for quantifying water and lipid concentrations in tissue

Thomas Livecchi, Anahita Pilvar, Ben Urban, Hrebesh Subhash, Steven Jacques, Darren Roblyer, Mark Pierce

Proceedings Volume 12363, 123630A (2023) https://doi.org/10.1117/12.2651290

KEYWORDS: Tissues, Water content, Skin, Short wave infrared radiation, Light sources and illumination, Biological samples, Biological imaging, Absorption, Chromophores, Scattering

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Proceedings Article | 15 March 2023 Poster + Paper

Poster + Paper

Using modern intraoral scanners for deep learning-assisted diagnostic solutions in dentistry

Abmael Oliveira, Ananya Jana, Hrebesh Subhash, Steven Jacques, Mark Pierce

Proceedings Volume 12363, 123630B (2023) https://doi.org/10.1117/12.2651291

KEYWORDS: Teeth, Scanners, Point clouds, Inflammation, 3D scanning, Tissues, Visualization, Cardiovascular disorders, Dentistry, Diagnostics

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Proceedings Article | 6 March 2023 Paper

Paper

Automatic tooth segmentation from 3D dental model using deep learning: a quantitative analysis of what can be learnt from a single 3D dental model

Ananya Jana, Hrebesh Molly Subhash, Dimitris Metaxas

Proceedings Volume 12567, 1256707 (2023) https://doi.org/10.1117/12.2669716

KEYWORDS: Teeth, Point clouds, 3D modeling, Education and training, Deep learning, 3D scanning, Machine learning, Network architectures, Image segmentation, Semantics

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SPIE Journal Paper | 12 October 2022 Open Access

Open Access

Spectral imaging of normal, hydrated, and desiccated porcine skin using polarized light

Ben Urban, Steven Jacques, Hrebesh Subhash

JBO, Vol. 27, Issue 10, 105001, (October 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.10.105001

KEYWORDS: Tissues, Reflectivity, Skin, Tissue optics, Imaging spectroscopy, Light emitting diodes, Cameras, Scattering, Collagen, Polarization

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Proceedings Article | 4 March 2022 Presentation + Paper

Presentation + Paper

Polarized light reflectance anisotropy measurement of hydrated and desiccated superficial porcine skin

Ben Urban, Steven Jacques, Hrebesh Subhash

Proceedings Volume 11963, 1196308 (2022) https://doi.org/10.1117/12.2615571

KEYWORDS: Tissues, Scattering, Polarization, Skin, Light scattering, Tissue optics

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Proceedings Article | 5 March 2021 Presentation + Paper

Presentation + Paper

Polarized light reflectance and the sub-diffuse regime during optical imaging of skin

Steven Jacques, Ben Urban, Hrebesh Subhash

Proceedings Volume 11646, 116460J (2021) https://doi.org/10.1117/12.2578004

KEYWORDS: Reflectivity, Scattering, Light scattering, Tissue optics, Mie scattering, Laser scattering, Tissues, Skin, Spherical lenses

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Proceedings Article | 9 March 2020 Presentation

Presentation

Integration of light-induced autofluorescence and optical coherence tomography for dental applications (Conference Presentation)

Nhan Le, Shaozhen Song, Hrebesh Subhash, Latonya Kilpatrick, Ruikang Wang

Proceedings Volume 11228, 1122812 (2020) https://doi.org/10.1117/12.2546967

KEYWORDS: Optical coherence tomography, Angiography, Tissues, Blood vessels, Real time imaging, Capillaries, In vivo imaging, Feature extraction, Imaging systems, Molecular imaging

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Proceedings Article | 2 March 2020 Presentation + Paper

Presentation + Paper

Artificial intelligence-based interactive virtual reality-assisted gaming system for hand rehabilitation

Mayaank Pillai, Yilin Yang, Corey Ditmars, Hrebesh Subhash

Proceedings Volume 11318, 113180J (2020) https://doi.org/10.1117/12.2549372

KEYWORDS: Virtual reality, Medical imaging, Motion controllers, Imaging systems, Detection and tracking algorithms, Gesture recognition, 3D modeling, Sensors, C++, Infrared cameras

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Proceedings Article | 4 March 2019 Presentation

Presentation

Ultra-sensitive label free imaging below the resolution limit (Conference Presentation)

Sergey Alexandrov, James McGrath, Colin Sheppard, Francesca Boccafoschi, Cinzia Giannini, Teresa Sibillano, Hrebesh Subhash, Josh Hogan, Martin Leahy

Proceedings Volume 10891, 1089106 (2019) https://doi.org/10.1117/12.2502479

KEYWORDS: Image resolution, Real time imaging, Spatial frequencies, Spatial resolution, Imaging systems, Super resolution microscopy, Fluorescent markers, In vivo imaging, Computer programming, Diffraction

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Proceedings Article | 15 March 2018 Presentation

Presentation

Plasmonic gold nanostars for biomedical imaging and theranostic applications (Conference Presentation)

Vijay Raghavan, Hrebesh Molly Subhash, Malini Olivo, Martin Leahy

Proceedings Volume 10493, 104930V (2018) https://doi.org/10.1117/12.2296712

KEYWORDS: Gold, Plasmonics, Biomedical optics, Near infrared, Nanoparticles, Photoacoustic imaging, Tumors, Continuous wave operation, Diagnostics, Image resolution

Read Abstract +

Nanoparticle contrast agents for targeted imaging have widespread diagnostic applications with cellular resolution, specificity and selectivity for visualization and assessment of various disease processes. Of particular interest are gold nanoparticles owing to the tunability of the localised surface plasmon resonance (LSPR) and its relative inertness. Synthesizing gold nanoprobes in the near infrared (NIR) region is of particular interest in developing nanosensors due to the minimal light attenuation from biomolecules. The ability of plasmonic gold nanostars (GNS), with novel shape-dependent dual LSPR, to elicit signal contrast at NIR wavelengths is described here for multiple biomedical modalities. First, the surface enhanced Raman scattering (SERS) capability of these dual plasmonic GNS has been demonstrated to elicit high SERS enhancement factor (EF) of 2 x 10e7 with 785 nm excitation and the potential to elicit the highest SERS EF ever reported for gold nanoparticles, with further longer wavelength excitations at and beyond 1064 nm. We have also demonstrated the longer wavelength contrast imaging capability of GNS with photoacoustic imaging (PAI) and for photothermal therapy (PTT). GNS possess unique structural characteristics that impart superior optical properties resulting in higher photothermal efficiency. The photothermal capability of GNS was demonstrated in vivo with localized temperature rise of 9℃ in tumors when irradiated with a 1064 nm CW laser that resulted in significant tumor cell death. Since photothermal conversion is the optical process responsible for eliciting PA contrast and for PTT, this development represents a novel theranostic substrate to be used at 1064 nm excitation, a longer wavelength than the conventional clinical range. The ability of GNS to elicit signal contrast at NIR wavelengths has also been demonstrated for photothermal optical coherence tomography (PT-OCT). When irradiated with a 1064 nm continuous wave laser, GNS elicited photothermal contrast well beyond 2 mm, displaying great potential for deep tissue imaging. We have also recently obtained a European Commission grant worth €5.98M on developing, demonstrating and validating a novel GNS enhanced photoacoustic imaging platform which will be capable of tracking mesenchymal stem cells (MSC) and MSC-derived exosomes, at unprecedented depth and sensitivity.

Proceedings Article | 28 March 2017 Paper

Paper

Comparing an FFT filter for multiple reference optical coherence tomography (MR-OCT) with an Chebychev and an elliptic filter

Kai Neuhaus, Sergey Alexandrov, Roshan Dsouza, Sean O'Gorman, Hrebesh Subhash, Josh Hogan, Carol Wilson, Paul McNamara, Martin Leahy

Proceedings Volume 10055, 100550X (2017) https://doi.org/10.1117/12.2253265

KEYWORDS: Optical coherence tomography, Point-of-care devices, Image filtering, Gaussian filters, Signal attenuation, Image processing, Signal processing, Electronic filtering, Signal to noise ratio

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Proceedings Article | 3 May 2016 Presentation

Presentation

Phase-sensitive multiple reference optical coherence tomography (Conference Presentation)

Roshan Dsouza, Hrebesh Subhash, Kai Neuhaus, Josh Hogan, Carol Wilson, Martin Leahy

Proceedings Volume 9699, 96990O (2016) https://doi.org/10.1117/12.2213574

KEYWORDS: Optical coherence tomography, Mirrors, In vivo imaging, Data modeling, Actuators, Medicine, Structural imaging, Doppler tomography, Blood vessels, Tissues

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SPIE Journal Paper | 12 April 2016 Open Access

Open Access

In vivo correlation mapping microscopy

James McGrath, Sergey Alexandrov, Peter Owens, Hrebesh Subhash, Martin Leahy

JBO, Vol. 21, Issue 04, 046004, (April 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.4.046004

KEYWORDS: Microscopy, Confocal microscopy, Capillaries, Optical coherence tomography, In vivo imaging, Video, Microscopes, Video microscopy, Visualization, Spatial resolution

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Proceedings Article | 5 April 2016 Presentation + Paper

Presentation + Paper

The how and why of a $10 optical coherence tomography system

M. Leahy, C. Wilson, J. Hogan, Peter O’Brien, R. Dsouza, K. Neuhaus, D. Bogue, H. Subhash, Colm O’Riordan, Paul McNamara

Proceedings Volume 9697, 96970T (2016) https://doi.org/10.1117/12.2213465

KEYWORDS: Optical coherence tomography, Compact discs, Biomedical optics, Biometrics, Mirrors, Eye, Skin cancer, Digital video discs, Imaging systems, Semiconductor lasers

Read Abstract +

Optical Coherence Tomography (OCT) is the fastest growing medical imaging modality with more than $1Bln worth of scans ordered and over $400M worth of equipment shipped in 2010, just nine years after its commercialization. It is at various stages of acceptance and approvals for eye care, coronary care and skin cancer care and is spreading rapidly to other medical specialties. Indeed, it is the leading success of translation of biophotonics science into clinical practice. Significant effort is being made to provide sufficient evidence for efficacy across a broad range of applications, but more needs to be done to radically reduce the cost of OCT so that it can spread to underserved markets and address new, fast growing opportunities in mobile health monitoring. Currently, a clinical OCT system ranges in price from ~$50k to ~$150k, typically is housed on a bedside trolley, runs off AC power, and requires skilled, extensively trained technicians to operate. The cost, size, and skill level required keep this wonderful technology beyond the reach of mainstream primary care, much less individual consumers seeking to monitor their health on a routine basis outside of typical clinical settings and major urban medical centers. Beyond the first world market, there are 6.5 billion people with similar eye and skin cancer care needs which cannot be met by the current generation of large, expensive, complex, and delicate OCT systems. This paper will describe a means to manufacture a low cost, compact, simple, and robust OCT system, using parts and a configuration similar to a CD-ROM or DVD pickup unit (see figure 1). Essentially, this system—multiple reference OCT (MR-OCT)—is based on the use of a partial mirror in the reference arm of a time domain OCT system to provide multiple references, and hence A-scans, at several depths simultaneously (see figure 2). We have already shown that a system based on this configuration can achieve an SNR of greater than 90 dB, which is sufficient for many medical imaging and biometry applications.

Proceedings Article | 21 March 2016 Paper

Paper

Quantitative assessment of rat corneal thickness and morphology during stem cell therapy by high-speed optical coherence tomography

Cerine Lal, James McGrath, Hrebesh Subhash, Sweta Rani, Thomas Ritter, Martin Leahy

Proceedings Volume 9693, 96931U (2016) https://doi.org/10.1117/12.2212821

KEYWORDS: Optical coherence tomography, Image segmentation, Image resolution, Stem cells, Optical imaging, Tissues, Medical imaging applications, Ophthalmology, Cornea, Iris, Eye, Injuries, Image processing, 3D image processing

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Proceedings Article | 21 March 2016 Paper

Paper

Optimization of modified scanning protocol based correlation mapping optical coherence tomography at 200 kHz VCSEL source for in vivo microcirculation imaging applications

Cerine Lal, James McGrath, Hrebesh Subhash, Martin Leahy

Proceedings Volume 9697, 96973C (2016) https://doi.org/10.1117/12.2214797

KEYWORDS: Optical coherence tomography, Angiography, Vertical cavity surface emitting lasers, In vivo imaging, Microcirculation imaging, Capillaries, Molecular spectroscopy, Visualization, Blood vessels, Diodes, Image resolution, Tissue optics, Tissues, Eye

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Proceedings Article | 9 March 2016 Presentation + Paper

Presentation + Paper

Novel contrast mechanism for label free super-resolution imaging

Sergey Alexandrov, James McGrath, Hrebesh Subhash, Francesca Boccafoschi, Cinzia Giannini, Martin Leahy

Proceedings Volume 9713, 971303 (2016) https://doi.org/10.1117/12.2207458

KEYWORDS: Super resolution, Optical microscopy, Spatial frequencies, Diffraction, Microscopy, Optical imaging, Computer programming, In vivo imaging, Spatial resolution, Spectral resolution, Imaging systems, Point spread functions, Convolution, Image resolution, Signal to noise ratio, Numerical simulations, Collagen

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Proceedings Article | 9 March 2016 Presentation + Paper

Presentation + Paper

Depth-dependent displacement sensitivity analysis and the influence of Doppler angle for quantitative assessment of mechanical properties using phase-sensitive spectral domain optical coherence tomography

Gillian Lynch, Hrebesh Subhash, Sergey Alexandrov, Martin Leahy

Proceedings Volume 9710, 97100N (2016) https://doi.org/10.1117/12.2210964

KEYWORDS: Optical coherence tomography, Elastography, Tissues, Doppler tomography, Tissue optics, Real time imaging, Scattering, Signal to noise ratio, Phase measurement, Soft tissue optics, Ferroelectric materials, Signal detection, Statistical analysis, Sensors

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Proceedings Article | 8 March 2016 Presentation + Paper

Presentation + Paper

The impact of relative intensity noise on the signal in multiple reference optical coherence tomography

Kai Neuhaus, Hrebesh Subhash, Sergey Alexandrov, Roshan Dsouza, Josh Hogan, Carol Wilson, Martin Leahy, Svetlana Slepneva, Guillaume Huyet

Proceedings Volume 9699, 96990P (2016) https://doi.org/10.1117/12.2211404

KEYWORDS: Optical coherence tomography, Interference (communication), Light emitting diodes, Mirrors, Interferometry, Optical scanning systems, Light sources, Signal to noise ratio, Sensors, Collimation, Spectrum analysis, Attenuators, Temperature metrology

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Proceedings Article | 12 March 2015 Paper

Paper

Characterization of light distribution and optimization of detector position for multiple reference optical coherence tomography

Kai Neuhaus, Hrebesh Subhash, Roshan Dsouza, Josh Hogan, Carol Wilson, Martin Leahy

Proceedings Volume 9314, 93140F (2015) https://doi.org/10.1117/12.2079744

KEYWORDS: Sensors, Mirrors, Zemax, Wavefronts, Point spread functions, Optical coherence tomography, Lenses, Optical simulations, Particle filters, Reflection

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Proceedings Article | 9 March 2015 Paper

Paper

Assessment of cutaneous melanoma and pigmented skin lesions with photoacoustic imaging

Aedán Breathnach, Liz Concannon, Laura Aalto, Jemima Dorairaj, Hrehesh Subhash, Jack Kelly, Martin Leahy

Proceedings Volume 9303, 930303 (2015) https://doi.org/10.1117/12.2078309

KEYWORDS: Melanoma, Photoacoustic imaging, Skin, Imaging systems, Sun, Linear filtering, Sensors, Digital imaging, Detection and tracking algorithms, Channel projecting optics

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Proceedings Article | 5 March 2015 Paper

Paper

Correlation mapping microscopy

James McGrath, Sergey Alexandrov, Peter Owens, Hrebesh Subhash, Martin Leahy

Proceedings Volume 9322, 93220L (2015) https://doi.org/10.1117/12.2077988

KEYWORDS: Microscopy, Confocal microscopy, Capillaries, Microscopes, Imaging systems, In vivo imaging, Image resolution, Optical coherence tomography, Associative arrays, Spatial resolution

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Proceedings Article | 2 March 2015 Paper

Paper

Signal simulation and signal processing for multiple reference optical coherence tomography

Kai Neuhaus, Hrebesh Subhash, Roshan Dsouza, Josh Hogan, Carol Wilson, Martin Leahy

Proceedings Volume 9312, 931236 (2015) https://doi.org/10.1117/12.2080994

KEYWORDS: Mirrors, Signal processing, Optical coherence tomography, Phase modulation, Image processing, Reflection, Sensors, Interferometry, Signal detection, Filtering (signal processing)

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SPIE Journal Paper | 23 December 2014 Open Access

Open Access

Linear-array-based photoacoustic imaging of human microcirculation with a range of high frequency transducer probes

Haroon Zafar, Aedán Breathnach, Hrebesh Subhash, Martin Leahy

JBO, Vol. 20, Issue 05, 051021, (December 2014) https://doi.org/10.1117/12.10.1117/1.JBO.20.5.051021

KEYWORDS: Transducers, Skin, In vivo imaging, 3D image processing, Photoacoustic imaging, Imaging systems, Image resolution, Tissue optics, Data acquisition, Microcirculation imaging

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Proceedings Article | 12 March 2014 Paper

Paper

High resolution coherence domain depth-resolved nailfold capillaroscopy based on correlation mapping optical coherence tomography

Hrebesh Subhash, Sean O'Gorman, Kai Neuhaus, Martin Leahy

Proceedings Volume 8951, 895106 (2014) https://doi.org/10.1117/12.2038550

KEYWORDS: Optical coherence tomography, Capillaries, Angiography, Coherence (optics), Image resolution, Biomedical optics, Tissues, Tissue optics, Diagnostics, Speckle

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Proceedings Article | 6 March 2014 Paper

Paper

Variation in cross-correlation as a discriminator for microvessel imaging using clinical intravascular optical coherence tomography systems

Shiju Joseph, Clément Rousseau, Hrebesh Subhash, Martin Leahy, David Adlam

Proceedings Volume 8934, 89342L (2014) https://doi.org/10.1117/12.2042053

KEYWORDS: Optical coherence tomography, Imaging systems, Capillaries, Tissues, Arteries, In vivo imaging, Biomedical optics, Distortion, Doppler tomography, Coherence imaging

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Proceedings Article | 4 March 2014 Paper

Paper

Photothermal optical coherence tomography for depth-resolved imaging of mesenchymal stem cells via single wall carbon nanotubes

Hrebesh Subhash, Emma Connolly, Mary Murphy, Valerie Barron, Martin Leahy

Proceedings Volume 8954, 89540C (2014) https://doi.org/10.1117/12.2038535

KEYWORDS: Optical coherence tomography, Single walled carbon nanotubes, Stem cells, Tissue engineering, 3D image processing, Cartilage, Tissues, Biomedical optics, In vitro testing, Scattering

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Proceedings Article | 4 March 2014 Paper

Paper

Nano-sensitive optical coherence tomography (nsOCT) for depth resolved characterization of 3D submicron structure

Sergey Alexandrov, Hrebesh Subhash, Azhar Zam, Martin Leahy

Proceedings Volume 8934, 89340Z (2014) https://doi.org/10.1117/12.2041921

KEYWORDS: Optical coherence tomography, Spatial frequencies, Scattering, 3D image processing, Spectral resolution, Imaging systems, Computer programming, Visualization, Tissues, Image resolution

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Proceedings Article | 4 March 2014 Paper

Paper

High-sensitive full-range optical vibrometry based on Fourier-domain optical coherence tomography

Hrebesh Subhash, Martin Leahy

Proceedings Volume 8934, 893436 (2014) https://doi.org/10.1117/12.2041861

KEYWORDS: Optical coherence tomography, Vibrometry, Mirrors, Interferometers, Biomedical optics, Coherence (optics), Phase modulation, Phase shifts, Fourier transforms, Range imaging

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Proceedings Article | 3 March 2014 Paper

Paper

Dual plasmonic gold nanoparticles for multispectral photoacoustic imaging application

Vijay Raghavan, Hrebesh Subhash, Aedán Breathnach, Martin Leahy, Peter Dockery, Malini Olivo

Proceedings Volume 8943, 89434J (2014) https://doi.org/10.1117/12.2042079

KEYWORDS: Absorption, Gold, Nanoparticles, Plasmons, Photoacoustic imaging, Multispectral imaging, Near infrared, Silver, Plasmonics, Photoacoustic spectroscopy

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Proceedings Article | 27 February 2014 Paper

Paper

Dermascope assisted interactive patient interface for multiple reference optical coherence tomography

Roshan Dsouza, Hrebesh Subhash, Kai Neuhaus, Josh Hogan, Carol Wilson, Martin Leahy

Proceedings Volume 8935, 89350B (2014) https://doi.org/10.1117/12.2038183

KEYWORDS: Mirrors, Optical coherence tomography, Skin, Imaging systems, Interfaces, Coherence imaging, Beam steering, Image registration, Linear filtering, Image acquisition

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Proceedings Article | 26 February 2014 Paper

Paper

Voice coil based robust and miniature optical delay for multiple reference optical coherence tomography

Roshan Dsouza, Hrebesh Subhash, Kai Neuhaus, Josh Hogan, Carol Wilson, Martin Leahy

Proceedings Volume 8942, 894207 (2014) https://doi.org/10.1117/12.2038471

KEYWORDS: Mirrors, Actuators, Optical coherence tomography, Tissue optics, Biomedical optics, Phase modulation, Image segmentation, Linear filtering, Solid state electronics, Ferroelectric materials

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Proceedings Article | 26 February 2014 Paper

Paper

Photoacoustic imaging of the human forearm using 40 MHz linear-array transducer

Haroon Zafar, Aedán Breathnach, Hrebesh Subhash, Martin Leahy

Proceedings Volume 8942, 89420M (2014) https://doi.org/10.1117/12.2040637

KEYWORDS: Transducers, Ultrasonography, Imaging systems, Skin, Photoacoustic imaging, In vivo imaging, Acquisition tracking and pointing, Image resolution, 3D image processing, Blood vessels

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Proceedings Article | 20 February 2014 Paper

Paper

Imaging mesenchymal stem cells containing single wall nanotube nanoprobes in a 3D scaffold using photo-thermal optical coherence tomography

Emma Connolly, Hrebesh Subhash, Martin Leahy, Niall Rooney, Frank Barry, Mary Murphy, Valerie Barron

Proceedings Volume 8954, 89540W (2014) https://doi.org/10.1117/12.2039829

KEYWORDS: Single walled carbon nanotubes, Nanoprobes, Optical coherence tomography, Imaging systems, Stem cells, 3D image processing, Tissues, Magnetic resonance imaging, Computed tomography, Neodymium

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SPIE Journal Paper | 16 December 2013 Open Access

Open Access

In vivo full-field en face correlation mapping optical coherence tomography

Paul McNamara, Hrebesh Subhash, Martin Leahy

JBO, Vol. 18, Issue 12, 126008, (December 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.12.126008

KEYWORDS: Optical coherence tomography, In vivo imaging, Imaging systems, Microscopes, Light sources, Cameras, Blood circulation, Mirrors, Objectives, Ferroelectric materials

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SPIE Journal Paper | 27 June 2013 Open Access

Open Access

Microcirculation imaging based on full-range high-speed spectral domain correlation mapping optical coherence tomography

Hrebesh Subhash, Martin Leahy

JBO, Vol. 19, Issue 02, 021103, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.19.2.021103

KEYWORDS: Optical coherence tomography, Imaging systems, Microcirculation imaging, Video, Capillaries, Mirrors, In vivo imaging, Image processing, Biomedical optics, Reconstruction algorithms

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Proceedings Article | 20 March 2013 Paper

Paper

Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea

Hrebesh Subhash, Ruikang Wang, Fangyi Chen, Alfred Nuttall

Proceedings Volume 8571, 85713G (2013) https://doi.org/10.1117/12.2002540

KEYWORDS: Optical coherence tomography, Reflectivity, Bone, Imaging systems, Functional imaging, Biomedical optics, Image resolution, Fourier transforms, Coherence (optics), Temporal resolution

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Proceedings Article | 20 March 2013 Paper

Paper

High-speed high-sensitivity spectral-domain correlation mapping optical coherence tomography based modified scanning protocol

Hrebesh Subhash, Martin Leahy

Proceedings Volume 8571, 85712I (2013) https://doi.org/10.1117/12.2006055

KEYWORDS: Optical coherence tomography, Tissue optics, In vivo imaging, Imaging systems, Skin, Biomedical optics, Angiography, Tissues, Cameras, Microcirculation imaging

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Proceedings Article | 8 March 2013 Paper

Paper

Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography

Sripriya Ramamoorthy, Yuan Zhang, Tracy Petrie, Fangyi Chen, Hrebesh Subhash, Niloy Choudhury, Ruikang Wang, Steven Jacques, Alfred Nuttall

Proceedings Volume 8565, 85651V (2013) https://doi.org/10.1117/12.2009260

KEYWORDS: Optical coherence tomography, Cameras, Scanning probe lithography, In vivo imaging, Ear, Reflectivity, Tissues, Signal to noise ratio, Data acquisition, Mirrors

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Proceedings Article | 8 March 2013 Paper

Paper

Expression and function of channelrhodopsin 2 in mouse outer hair cells

Fangyi Chen, Tao Wu, Teresa Wilson, Hrebesh Subhash, Irina Omelchenko, Michael Bateschell, Lingyan Wang, John Brigande, Zhi-Gen Jiang, Alfred Nuttall

Proceedings Volume 8586, 85860I (2013) https://doi.org/10.1117/12.2003114

KEYWORDS: Optogenetics, Systems modeling, Uterus, Fluorescent markers, Ear, Modulation, Light emitting diodes, Axons, Resistance, In vivo imaging

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SPIE Journal Paper | 1 March 2013 Open Access

Open Access

Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry

Hrebesh Subhash, Niloy Choudhury, Fangyi Chen, Ruikang Wang, Steven Jacques, Alfred Nuttall

JBO, Vol. 18, Issue 03, 036003, (March 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.3.036003

KEYWORDS: Optical coherence tomography, Vibrometry, Interferometry, Imaging systems, Tissue optics, Glasses, Doppler effect, Acoustics, Laser Doppler velocimetry, Calibration

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Proceedings Article | 1 March 2013 Paper

Paper

In vivo microcirculation imaging of the sub surface fingertip using correlation mapping optical coherence tomography (cmOCT)

Roshan Dsouza, Azhar Zam, Hrebesh Subhash, Kirill Larin, Martin Leahy

Proceedings Volume 8580, 85800M (2013) https://doi.org/10.1117/12.2002384

KEYWORDS: Optical coherence tomography, Biometrics, Capillaries, Information security, Glasses, Microcirculation imaging, In vivo imaging, Biomedical optics, Fingerprint recognition, System identification

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Proceedings Article | 1 March 2013 Paper

Paper

High-speed full-range spectral-domain correlation mapping optical coherence tomography

Hrebesh Subhash, Martin Leahy

Proceedings Volume 8580, 85800Y (2013) https://doi.org/10.1117/12.2003244

KEYWORDS: Optical coherence tomography, Mirrors, Imaging systems, Modulation, Skin, Angiography, In vivo imaging, Biomedical optics, Spectroscopy, Deep tissue imaging

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Proceedings Article | 1 March 2013 Paper

Paper

Multiple reference optical coherence tomography (MR-OCT) system

Martin Leahy, Josh Hogan, Carol Wilson, Hrebesh Subhash, Roshan Dsouza

Proceedings Volume 8580, 85800L (2013) https://doi.org/10.1117/12.2002480

KEYWORDS: Mirrors, Optical coherence tomography, Signal detection, Reflection, Ferroelectric materials, Imaging systems, Signal to noise ratio, Sensors, Image analysis, Scanners

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SPIE Journal Paper | 6 June 2012 Open Access

Open Access

Feasibility of spectral-domain phase-sensitive optical coherence tomography for middle ear vibrometry

Hrebesh Subhash, Steven Jacques, Anh Nguyen-Huynh, Alfred Nuttall, Ruikang Wang, Niloy Choudhury

JBO, Vol. 17, Issue 6, 060505, (June 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.6.060505

KEYWORDS: Optical coherence tomography, Ear, Bone, Vibrometry, Acoustics, Imaging systems, Fourier transforms, Phase measurement, Phase shift keying, Biomedical engineering

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Proceedings Article | 18 February 2012 Paper

Paper

Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography

Hrebesh Subhash, Niloy Choudhury, Steven Jacques, Ruikang Wang, Fangyi Chen, Dingjun Zha, Alfred Nuttall

Proceedings Volume 8213, 82131V (2012) https://doi.org/10.1117/12.907900

KEYWORDS: Optical coherence tomography, Objectives, Signal to noise ratio, Fourier transforms, Mechanics, Vibrometry, Biomedical optics, Mirrors, Glasses, Imaging systems

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Proceedings Article | 18 February 2012 Paper

Paper

Simultaneous depth-resolved imaging of sub-nanometer scale ossicular vibrations and morphological features of the human-cadaver middle ear with spectral-domain phase-sensitive optical coherence tomography

Hrebesh Subhash, Anh Nguyen-Huynh, Ruikang Wang, Steven Jacques, Alfred Nuttall

Proceedings Volume 8207, 82072C (2012) https://doi.org/10.1117/12.920839

KEYWORDS: Ear, Optical coherence tomography, Vibrometry, Bone, Americium, Doppler tomography, Fourier transforms, Acoustics, Sensors, Laser Doppler velocimetry

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Proceedings Article | 17 June 2011 Paper

Paper

Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography

Hrebesh Subhash, Hui Xie, Jeffrey Smith, Owen McCarty

Proceedings Volume 8091, 809108 (2011) https://doi.org/10.1117/12.889760

KEYWORDS: Nanoparticles, Optical coherence tomography, Particles, Tissues, Near infrared, Polymers, Absorption, Biomedical optics, Imaging systems, Tissue optics

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Proceedings Article | 12 February 2011 Paper

Paper

Volumetric in-vivo imaging of intra-cochlear microstructures and microvascular perfusion in mice using high-speed spectral domain optical coherence tomography and ultra-high sensitive optical microangiography

Hrebesh Subhash, Viviana Davila, Hai Sun, Anh Nguyen-Huynh, Alfred Nuttall, Ruikang Wang

Proceedings Volume 7889, 78892V (2011) https://doi.org/10.1117/12.874182

KEYWORDS: In vivo imaging, Optical coherence tomography, 3D image processing, Ear, Tissue optics, 3D image reconstruction, Imaging systems, Biomedical optics, Visualization, Magnetic resonance imaging

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SPIE Journal Paper | 1 May 2010 Open Access

Open Access

Volumetric in vivo imaging of intracochlear microstructures in mice by high-speed spectral domain optical coherence tomography

Hrebesh Subhash, Viviana Davila, Hai Sun, Anh Nguyen-Huyn, Alfred Nuttall, Ruikang Wang

JBO, Vol. 15, Issue 03, 036024, (May 2010) https://doi.org/10.1117/12.10.1117/1.3456554

KEYWORDS: Optical coherence tomography, In vivo imaging, Imaging systems, 3D image processing, Ear, Visualization, Cameras, Video, Magnetic resonance imaging, Medicine

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Proceedings Article | 12 March 2010 Paper

Paper

Ultra-high speed full range complex spectral domain optical coherence tomography for volumetric imaging at 140,000 A scans per second

Hrebesh Subhash, Lin An, Ruikang Wang

Proceedings Volume 7554, 75540K (2010) https://doi.org/10.1117/12.842944

KEYWORDS: Imaging systems, Optical coherence tomography, Modulation, In vivo imaging, Image segmentation, Eye, Range imaging, CMOS cameras, Mirrors, Software development

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SPIE Journal Paper | 1 March 2010 Open Access

Open Access

High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiography

Lin An, Hrebesh Subhush, David Wilson, Ruikang Wang

JBO, Vol. 15, Issue 02, 026011, (March 2010) https://doi.org/10.1117/12.10.1117/1.3369811

KEYWORDS: Blood vessels, Optical coherence tomography, Retina, Eye, Blood, Retinal scanning, Image segmentation, Tissues, Phase compensation, Motion estimation

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Proceedings Article | 20 February 2009 Paper

Paper

Real-time single-shot full-field OCT based on dual-channel phase-stepper optics and 2D quaternionic analytic signal processing

Molly Subhash Hrebesh, Manabu Sato

Proceedings Volume 7168, 71681H (2009) https://doi.org/10.1117/12.807838

KEYWORDS: Optical coherence tomography, Signal analyzers, Signal processing, Spatial frequencies, Interferometers, Polarization, CCD cameras, Image resolution, Scattering, Charge-coupled devices

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Proceedings Article | 28 February 2008 Paper

Paper

Single-shot full-field OCT based on four quadrature phase-stepped interferometer

Molly Subhash Hrebesh, Yuuki Watanabe, Razvan Dabu, Manabu Sato

Proceedings Volume 6847, 684717 (2008) https://doi.org/10.1117/12.759615

KEYWORDS: Optical coherence tomography, Imaging systems, Beam splitters, Interferometers, Mirrors, Polarization, Wave plates, CCD cameras, 3D image processing, Charge-coupled devices

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Showing 5 of 62 publications

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