Collagen crosslinking and degradation have been associated with changes in tissue stiffness. Although femtosecond laser irradiation might induce either collagen crosslinking or collagen degradation, the photomodulation effects are still unclear. Our goal was to characterize effects of photomodulation. We found that collagen crosslinking and degradation were related to the number of treatments, and photomodulation-involved reactants diffuse. The precision of photomodulation was at the micrometer level in both lateral and axial directions. Polarized light microscopy shows no change in collagen architecture in the treatment boundary and without the production of damaging thermoacoustic effects.
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