Dr. Guangying Guan Profile

Dr. Guangying Guan

Lab. Manager at Univ of Dundee

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Publications (11)

Proceedings Article | 7 February 2018 Presentation + Paper

Quantitative assessment of the mechanical properties of prostate tissue with optical coherence elastography

Yuting Ling, Chunhui Li, Kanheng Zhou, Guangying Guan, Stephen Lang, David McGloin, Ghulam Nabi, Zhihong Huang

Proceedings Volume 10468, 104680A (2018) https://doi.org/10.1117/12.2288485

KEYWORDS: Prostate cancer, Biopsy, Prostate, Elastography, Optical coherence tomography

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Proceedings Article | 5 March 2015 Paper

Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods

Chunhui Li, Guangying Guan, Zhihong Huang, Ruikang Wang, Ghulam Nabi

Proceedings Volume 9322, 93220O (2015) https://doi.org/10.1117/12.2075666

KEYWORDS: Skin, Elastography, Actuators, In vivo imaging, Optical coherence tomography, Tissue optics, Tissues, Signal detection, Acoustics, Coherence (optics)

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Proceedings Article | 5 March 2015 Paper

Application of new optical coherence elastography to monitor the mineralization processing in bone tissue engineering constructs

Guangying Guan, Shaozhen Song, Zhihong Huang, Ying Yang

Proceedings Volume 9322, 93220G (2015) https://doi.org/10.1117/12.2078013

KEYWORDS: Bone, Particles, Elastography, Tissues, Tissue engineering, Tissue optics, Coherence (optics), In vitro testing, Modulation, Acoustics

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Proceedings Article | 2 March 2015 Paper

Optical coherence elastography (OCE) as a method for identifying benign and malignant prostate biopsies

Chunhui Li, Guangying Guan, Yuting Ling, Stephen Lang, Ruikang Wang, Zhihong Huang, Ghulam Nabi

Proceedings Volume 9312, 93122S (2015) https://doi.org/10.1117/12.2075711

KEYWORDS: Prostate, Biopsy, Tissues, Elastography, Prostate cancer, Cancer, Optical coherence tomography, Principal component analysis, Coherence (optics), Image resolution

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Objectives. Prostate cancer is the most frequently diagnosed malignancy in men. Digital rectal examination (DRE) - a known clinical tool based on alteration in the mechanical properties of tissues due to cancer has traditionally been used for screening prostate cancer. Essentially, DRE estimates relative stiffness of cancerous and normal prostate tissue. Optical coherence elastography (OCE) are new optical imaging techniques capable of providing cross-sectional imaging of tissue microstructure as well as elastogram in vivo and in real time. In this preliminary study, OCE was used in the setting of the human prostate biopsies ex vivo, and the images acquired were compared with those obtained using standard histopathologic methods. Methods. 120 prostate biopsies were obtained by TRUS guided needle biopsy procedures from 9 patients with clinically suspected cancer of the prostate. The biopsies were approximately 0.8mm in diameter and 12mm in length, and prepared in Formalin solution. Quantitative assessment of biopsy samples using OCE was obtained in kilopascals (kPa) before histopathologic evaluation. The results obtained from OCE and standard histopathologic evaluation were compared provided the cross-validation. Sensitivity, specificity, and positive and negative predictive values were calculated for OCE (histopathology was a reference standard). Results. OCE could provide quantitative elasticity properties of prostate biopsies within benign prostate tissue, prostatic intraepithelial neoplasia, atypical hyperplasia and malignant prostate cancer. Data analysed showed that the sensitivity and specificity of OCE for PCa detection were 1 and 0.91, respectively. PCa had significantly higher stiffness values compared to benign tissues, with a trend of increasing in stiffness with increasing of malignancy. Conclusions. Using OCE, microscopic resolution elastogram is promising in diagnosis of human prostatic diseases. Further studies using this technique to improve the detection and staging of malignant cancer of the prostate are ongoing.

SPIE Journal Paper | 5 November 2013 Open Access

Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method

Guangying Guan, Chunhui Li, Yuting Ling, Ying Yang, Jan Vorstius, Robert Keatch, Ruikang Wang, Zhihong Huang

JBO, Vol. 18, Issue 11, 111417, (November 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.11.111417

KEYWORDS: Elastography, Optical coherence tomography, Acoustics, Tissues, Magnesium, Biomedical optics, Coherence (optics), Signal detection, Collagen, Ultrasonography

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SPIE Journal Paper | 3 May 2012 Open Access

Evaluating elastic properties of heterogeneous soft tissue by surface acoustic waves detected by phase-sensitive optical coherence tomography

Chunhui Li, Guangying Guan, Ruikang Wang, Sinan Li, Zhihong Huang

JBO, Vol. 17, Issue 5, 057002, (May 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.5.057002

KEYWORDS: Tissues, Natural surfaces, Skin, Phase velocity, Acoustics, Optical coherence tomography, Interfaces, Tissue optics, Breast, Signal detection

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SPIE Journal Paper | 31 January 2012 Open Access

Multifunctional nanoprobe to enhance the utility of optical based imaging techniques

Yeongri Jung, Guangying Guan, Chen-Wei Wei, Roberto Reif, Xiaohu Gao, Matthew O'Donnell, Ruikang Wang

JBO, Vol. 17, Issue 1, 016015, (January 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.1.016015

KEYWORDS: Magnetism, Optical coherence tomography, Nanoparticles, Nanoprobes, Gold, Optical imaging, Absorption, Particles, Imaging systems, Scattering

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Proceedings Article | 30 January 2012 Paper

Depth profile absorber concentration reconstruction using photothermal optical coherence tomography

Roberto Reif, Guangying Guan, Ruikang Wang

Proceedings Volume 8213, 82132G (2012) https://doi.org/10.1117/12.910983

KEYWORDS: Optical coherence tomography, Solids, Temperature metrology, Refraction, Laser scattering, Scattering, Tissues, Tissue optics, Light scattering, Absorption

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Proceedings Article | 30 January 2012 Paper

Quantitative elastography of skin and skin lesion using phase-sensitive OCT (PhS-OCT) and surface wave method

Chunhui Li, Guangying Guan, Zhihong Huang, Ruikang Wang

Proceedings Volume 8213, 82132E (2012) https://doi.org/10.1117/12.910985

KEYWORDS: Skin, Phase velocity, Elastography, Optical coherence tomography, Natural surfaces, In vivo imaging, Signal detection, Tissues, Imaging systems, Dispersion

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SPIE Journal Paper | 1 December 2011 Open Access

Depth profiling of photothermal compound concentrations using phase sensitive optical coherence tomography

Guangying Guan, Roberto Reif, Ruikang Wang, Zhihong Huang

JBO, Vol. 16, Issue 12, 126003, (December 2011) https://doi.org/10.1117/12.10.1117/1.3659211

KEYWORDS: Tissues, Optical coherence tomography, Solids, Profiling, Signal attenuation, Scattering, Natural surfaces, Temperature metrology, Refraction, Liquids

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SPIE Journal Paper | 1 June 2011 Open Access

High-speed 1310 nm-band spectral domain optical coherence tomography at 184,000 lines per second

Lin An, Guangying Guan, Ruikang Wang

JBO, Vol. 16, Issue 06, 060506, (June 2011) https://doi.org/10.1117/12.10.1117/1.3592492

KEYWORDS: Imaging systems, Cameras, Spectrometers, Line scan image sensors, Optical coherence tomography, Indium gallium arsenide, Control systems, Doppler tomography, In vivo imaging, Image quality

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