Monitoring of photodynamic therapy with target nanoconstructs by fluorescence and optoacoustic imaging: numerical simulations and phantom study

I. V. Turchin; M. Yu. Kirillin; D. A. Kurakina; V. V. Perekatova; A. G. Orlova; E. A. Sergeeva; V. I. Plehanov; A. V. Khilov; P. V. Subochev; S. Mallidi; T. Hasan

doi:10.1117/12.2527016

22 July 2019 Monitoring of photodynamic therapy with target nanoconstructs by fluorescence and optoacoustic imaging: numerical simulations and phantom study

I. V. Turchin, M. Yu. Kirillin, D. A. Kurakina, V. V. Perekatova, A. G. Orlova, E. A. Sergeeva, V. I. Plehanov, A. V. Khilov, P. V. Subochev, S. Mallidi, T. Hasan

Author Affiliations +

Proceedings Volume 11079, Medical Laser Applications and Laser-Tissue Interactions IX; 110790O (2019) https://doi.org/10.1117/12.2527016
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

We propose a new approach to monitoring of photodynamic therapy (PDT) of glioblastoma with the use of targeted nanoconstructs containing a photosensitizer (PS) benzoporphyrin derivative (BPD) and IRDye800 dye, antibodies for efficient accumulation of the drug in a tumor, and a chemotherapeutic agent for combined effect on tumor cells. Monitoring of PDT is based on the simultaneous fluorescent and optoacoustic (OA) imaging. Fluorescent imaging provides visualization of fluorescence agents with high molecular sensitivity, and monitoring of the effectiveness of PDT by PS photobleaching. OA allows to examine the vascular pattern of the tumor environment, as well as assess the tumor depth. IRDye800 is a better contrast agent in comparison to BPD due to red shifted spectral characteristics and higher fluorescence quantum yield. The results of numerical simulations have been verified in phantom studies using fluorescence and optoacoustic experimental setups and an agar phantom with optical characteristics similar to those of murine brain.

Citation Download Citation

I. V. Turchin, M. Yu. Kirillin, D. A. Kurakina, V. V. Perekatova, A. G. Orlova, E. A. Sergeeva, V. I. Plehanov, A. V. Khilov, P. V. Subochev, S. Mallidi, and T. Hasan "Monitoring of photodynamic therapy with target nanoconstructs by fluorescence and optoacoustic imaging: numerical simulations and phantom study", Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 110790O (22 July 2019); https://doi.org/10.1117/12.2527016

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