Dr. Anna G. Orlova Profile

Dr. Anna G. Orlova

Researcher at Institute of Applied Physics RAS

SPIE Involvement:

Author

Publications (39)

Proceedings Article | 3 March 2022 Presentation + Paper

Multimodal optical monitoring of auto and allografts of skin on a burn wound

Maksim Ryabkov, Vladimir Beschastnov, Ksenia Petrova, Petr Peretyagin, Anna Orlova, Aleksey Kostyuk, Ilya Turchin, Marina Bugrova, Igor Yu Arefiev

Proceedings Volume 11934, 1193402 (2022) https://doi.org/10.1117/12.2609580

KEYWORDS: Skin, Optical coherence tomography, Transplantation, Tissue optics, Tissues, Blood, Mode conditioning cables, Ocean optics, Light, Visualization

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Proceedings Article | 9 December 2021 Paper

PVDF spherical matrix array for high resolution cerebral optoacoustic micro-angiography of rodents

Pavel Subochev, Xose Luis Dean-Ben, Zhenyue Chen, Anna Orlova, Daniel Razansky

Proceedings Volume 11923, 119230W (2021) https://doi.org/10.1117/12.2615920

KEYWORDS: Ferroelectric polymers, Spherical lenses, Antennas, Optoacoustics, 3D image processing, Sensors, In vivo imaging, Algorithm development, Signal detection, Reconstruction algorithms

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Proceedings Article | 9 December 2021 Paper

Optoacoustic angiography for assessment of experimental tumor vascular reaction to radiation therapy

Ksenia Pavlova, Anna Orlova, Aleksey Kurnikov, Anna Maslennikova, Alexander Khilov, Valeria Perekatova, Dmitriy Skamnitsky, Pavel Subochev

Proceedings Volume 11923, 119230U (2021) https://doi.org/10.1117/12.2615916

KEYWORDS: Tumors, Radiotherapy, Optoacoustics, Tissues, Image segmentation, Blood vessels, Angiography, Visualization, Ultrasonics, Reconstruction algorithms

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Proceedings Article | 9 December 2021 Paper

Applications of raster-scan optoacoustic angiography in experimental oncology

Anna Orlova, Ksenia Pavlova, Aleksey Kurnikov, Marina Sirotkina, Anna Maslennikova, Aleksandr Khilov, Valeria Perekatova, Dmitriy Skamnitsky, Ilya Turchin, Pavel Subochev

Proceedings Volume 11923, 119230T (2021) https://doi.org/10.1117/12.2615914

KEYWORDS: Tumors, Angiography, Blood vessels, Optoacoustics, Oncology, Tumor growth modeling, Animal model studies, Tissues, Radiotherapy, Colon

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Proceedings Article | 9 December 2021 Paper

Wideband ultrasound PVDF detectors for raster-scan optoacoustic angiography

Alexey Kurnikov, Ksenia Pavlova, Anna Orlova, Aleksandr Khilov, Valeriya Perekatova, Andrey Kovalchuk, Pavel Subochev

Proceedings Volume 11923, 119230K (2021) https://doi.org/10.1117/12.2615901

KEYWORDS: Angiography, Sensors, Antennas, Tumors, Visualization, Ultrasonography, Tissues, Ferroelectric polymers, Optoacoustics, Blood vessels

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Proceedings Article | 9 December 2021 Paper

Quantification of microvasculature parameters in normal and pathological tissues based on three-dimensional raster-scan optoacoustic angiography

Valeriya Perekatova, Mikhail Kirillin, Ilya Turchin, Aleksandr Khilov, Svetlana Nemirova, Alexey Kurnikov, Anna Orlova, Ksenia Pavlova, Vyacheslav Kazakov, Pavel Subochev

Proceedings Volume 11923, 1192314 (2021) https://doi.org/10.1117/12.2615992

KEYWORDS: Tumors, Tissues, Skin, Algorithm development, 3D image processing, Angiography, 3D image reconstruction, Optoacoustics, Reconstruction algorithms, In vivo imaging

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Proceedings Article | 7 December 2021 Paper

Red and blue light in photodynamic therapy with chlorin-based photosensitizers

Mikhail Kirillin, Daria Kurakina, Aleksandr Khilov, Anna Orlova, Maria Shakhova, Ksenia Pavlova, Valeria Perekatova, Natalia Orlinskaya, Ekaterina Sergeeva

Proceedings Volume 11919, 119191K (2021) https://doi.org/10.1117/12.2614871

KEYWORDS: Phototherapy, Photodynamic therapy, Tissue optics, Medical research, Medical diagnostics, Light scattering, In vivo imaging, Applied physics

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Proceedings Article | 7 December 2021 Paper

Fluorescence and optoacoustics monitoring of tumor treatment with novel agents for combined photodynamic and chemotherapy

I. Turchin, M. Kirillin, A. Orlova, V. Perekatova, V. Plekhanov, E. Sergeeva, D. Kurakina, A. Khilov, A. Kurnikov, P. Subochev, M. Shirmanova, A. Komarova, D. Yuzhakova, A. Gavrina, S. Bano, S. Mallidi, T. Hasan

Proceedings Volume 11919, 119191J (2021) https://doi.org/10.1117/12.2614869

KEYWORDS: Tumors, Photodynamic therapy, Luminescence, Optoacoustics, IRIS Consortium, Tissues, Picosecond phenomena, Laser irradiation, Cancer, Reconstruction algorithms

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Proceedings Article | 5 March 2021 Presentation + Paper

In vivo applications of raster-scan optoacoustic angiography

Anna Orlova, Ksenia Pavlova, Aleksey Kurnikov, Marina Sirotkina, Anna Maslennikova, Mikhail Yu. Kirillin, Dmitriy Skamnitsky, Ilya Turchin, Pavel Subochev

Proceedings Volume 11642, 1164209 (2021) https://doi.org/10.1117/12.2578206

KEYWORDS: Angiography, Optoacoustics, In vivo imaging, Blood vessels, Tumors, Skin, Blood, Tissues, Tissue optics, Soft tissue optics

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Proceedings Article | 5 March 2021 Presentation + Paper

Polymer-based spherical matrix array for high resolution real-time volumetric optoacoustic micro-angiography

Pavel Subochev, Xosé Luís Deán-Ben, Zhenyue Chen, Anna Orlova, Daniel Razansky

Proceedings Volume 11642, 116421V (2021) https://doi.org/10.1117/12.2579204

KEYWORDS: Spherical lenses, Optoacoustics, Polymers, Visualization, Tomography, Ultrasonography, Ultrafast imaging, Tissues, Time resolved spectroscopy, Spectroscopy

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Proceedings Article | 5 March 2021 Presentation + Paper

Optimization of light and sound delivery for in vivo whole-brain optoacoustic angiography of rodents

Pavel Subochev, Ekaterina Sergeeva, Mikhail Kirillin, Daria Kurakina, Anna Orlova, Alexey Kurnikov, Xosé Luís Deán-Ben, Zhenyue Chen, Daniel Razansky

Proceedings Volume 11642, 116422N (2021) https://doi.org/10.1117/12.2579210

KEYWORDS: Optoacoustics, In vivo imaging, Brain, Angiography, Neuroimaging, Signal generators, Imaging systems, Acoustics, Visible radiation, Tissues

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Proceedings Article | 20 April 2020 Presentation

Optoacoustic monitoring of angiogenesis in experimental tumors (Conference Presentation)

Anna Gennadjevna Orlova, Ilya Turchin

Proceedings Volume 11240, 112400P (2020) https://doi.org/10.1117/12.2550810

KEYWORDS: Tumors, Optoacoustics, Angiography, Diagnostics, Colon, Cancer, Oncology

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Proceedings Article | 19 February 2020 Paper

Combined fluorescence and optoacoustic imaging for monitoring the efficiency of photodynamic therapy with BPD-based nanoconstructs

I. Turchin, M. Kirillin, D. Kurakina, A. Orlova, V. Plekhanov, E. Sergeeva, P. Subochev, E. Sergeev, V. Perekatova, A. Nerush, D. Yuzhakova, E. Kiseleva, M. Shirmanova, S. Bano, S. Mallidi, T. Hasan

Proceedings Volume 11220, 112200V (2020) https://doi.org/10.1117/12.2565087

KEYWORDS: Tumors, Photodynamic therapy, Luminescence, Tissues, Optoacoustics, Visualization, Imaging systems, Absorption, Pulsed laser operation, Blood

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Proceedings Article | 22 July 2019 Paper

Hydrogen peroxide level in tumor cells during cisplatin-induced apoptosis

Anastasiya Nerush, Kseniya Shсhukina, Irina Balalaeva, Anna Orlova

Proceedings Volume 11079, 110791M (2019) https://doi.org/10.1117/12.2527195

KEYWORDS: Cell death, Hydrogen, Tumors, Luminescence, Flow cytometry, Sensors, Cancer, Optical filters, Medicine, Applied physics

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Proceedings Article | 22 July 2019 Paper

Red and blue light photodynamic therapy regimes: optical monitoring and histology studies

Mikhail Kirillin, Maria Shakhova, Daria Kurakina, Aleksandr Khilov, Anna Orlova, Ekaterina Sergeeva, Alina Meller, Natalia Orlinskaya, Ilya Turchin

Proceedings Volume 11079, 110790R (2019) https://doi.org/10.1117/12.2527061

KEYWORDS: Photodynamic therapy, Tumors, Picosecond phenomena, Luminescence, Optical coherence tomography, Tissues, Tissue optics, Monte Carlo methods, Optical diagnostics, Phototherapy

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Proceedings Article | 22 July 2019 Paper

Monitoring of photodynamic therapy with target nanoconstructs by fluorescence and optoacoustic imaging: numerical simulations and phantom study

I. Turchin, M. Yu. Kirillin, D. Kurakina, V. Perekatova, A. Orlova, E. Sergeeva, V. Plehanov, A. Khilov, P. Subochev, S. Mallidi, T. Hasan

Proceedings Volume 11079, 110790O (2019) https://doi.org/10.1117/12.2527016

KEYWORDS: Luminescence, Photodynamic therapy, Tumors, Optoacoustics, Numerical simulations, Monte Carlo methods, Absorption, Picosecond phenomena, Brain, Tissues

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Proceedings Article | 19 July 2019 Paper

Optoacoustic angiography of experimental tumors

Anna Orlova, Marina Sirotkina, Ekaterina Smolina, Vadim Elagin, Ilya Turchin, Pavel Subochev

Proceedings Volume 11077, 1107711 (2019) https://doi.org/10.1117/12.2527148

KEYWORDS: Tumors, Angiography, Optoacoustics, Blood vessels, Diagnostics, Tumor growth modeling, Oncology, Visualization, Natural surfaces, Tissues

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Proceedings Article | 19 July 2019 Paper

Analysis of different approaches for blood oxygenation determination from multispectral optoacoustic measurements

I. Turchin, V. Perekatova, M. Yu. Kirillin, D. Kurakina, A. Orlova, P. Subochev

Proceedings Volume 11077, 110770B (2019) https://doi.org/10.1117/12.2526988

KEYWORDS: In vivo imaging, In vitro testing, Blood, Absorption, Blood oxygen saturation, Signal attenuation, Optoacoustics, Blood vessels, Calibration, Veins

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SPIE Journal Paper | 22 May 2018 Open Access

Wideband linear detector arrays for optoacoustic imaging based on polyvinylidene difluoride films

Pavel Subochev, Maxim Prudnikov, Vladimir Vorobyev, Anna Postnikova, Egor Sergeev, Valeria Perekatova, Anna Orlova, Valentina Kotomina, Ilya Turchin

JBO, Vol. 23, Issue 09, 091408, (May 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.9.091408

KEYWORDS: Ferroelectric polymers, Detector arrays, Optoacoustics, In vivo imaging, Acoustics, Imaging arrays, Electrodes, Signal to noise ratio, Pulsed laser operation, Biomedical optics

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SPIE Journal Paper | 15 May 2018 Open Access

Multimodal approach in assessment of the response of breast cancer to neoadjuvant chemotherapy

Mikhail Pavlov, Tatiana Kalganova, Yekaterina Lyubimtseva, Vladimir Plekhanov, German Yurievich Golubyatnikov, Olga Ilyinskaya, Anna Orlova, Pavel Subochev, Dmitriy Safonov, Natalia Shakhova, Anna Maslennikova

JBO, Vol. 23, Issue 09, 091410, (May 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.9.091410

KEYWORDS: Tumors, Oxygen, Blood circulation, Computed tomography, Breast, Breast cancer, Tissues, Ultrasonography, Doppler effect, X-ray computed tomography

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Proceedings Article | 28 July 2017 Paper

Oxygenation level and hemoglobin concentration in experimental tumor estimated by diffuse optical spectroscopy

A. Orlova, M. Yu. Kirillin, A. Volovetsky, N. Yu. Shilyagina, E. Sergeeva, G. Yu. Golubiatnikov, I. Turchin

Proceedings Volume 10411, 104110X (2017) https://doi.org/10.1117/12.2284793

KEYWORDS: Tumors, Diffuse optical spectroscopy, Oxygen

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Proceedings Article | 28 July 2017 Paper

A technique for measuring oxygen saturation in biological tissues based on diffuse optical spectroscopy

Mikhail Kleshnin, Anna Orlova, Mikhail Kirillin, German Golubiatnikov, Ilya Turchin

Proceedings Volume 10412, 1041212 (2017) https://doi.org/10.1117/12.2284378

KEYWORDS: Tissues, Diffuse optical spectroscopy, Oxygen, Blood

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Proceedings Article | 28 July 2017 Paper

Fiber-based time-resolved fluorescence and phosphorescence spectroscopy of tumors

M. Shirmanova, M. Lukina, A. Orlova, H. Studier, E. Zagaynova, W. Becker, V. Shcheslavskiy

Proceedings Volume 10413, 104130I (2017) https://doi.org/10.1117/12.2284185

KEYWORDS: Time resolved spectroscopy, Phosphorescence, Tumors, Fluorescence spectroscopy, Spectroscopy, Single photon, Fluorescence lifetime imaging, Luminescence, Fiber optics

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Proceedings Article | 24 April 2017 Presentation

Simultaneous in vivo imaging of diffuse optical reflectance, optoacoustic pressure and ultrasonic scattering (Conference Presentation)

Pavel Subochev, Anna Orlova, Ilya Turchin

Proceedings Volume 10064, 100640S (2017) https://doi.org/10.1117/12.2251998

KEYWORDS: Scattering, In vivo imaging, Tissue optics, Ultrasonics, Acoustics, Sensors, Photons, Imaging systems, Diagnostics, Reflectivity

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Proceedings Article | 17 February 2017 Paper

The complex evaluation of tumor oxygen state and vasculature during preoperative chemotherapy in patients with breast cancer

M. Pavlov, P. Subochev, T. Kalganova, G. Yu. Golubyatnikov, V. Plekhanov, O. Ilyinskaya, A. Orlova, N. Shakhova, A. Maslennikova

Proceedings Volume 10059, 100590P (2017) https://doi.org/10.1117/12.2251419

KEYWORDS: Blood, Breast cancer, Ultrasonography, Optical spectroscopy, Spectroscopy, Breast, Mode conditioning cables, Doppler tomography, Optical tomography, Tissue optics, Tumors, Oxygen, Tissues, Imaging spectroscopy, Doppler effect, Blood circulation, Optical imaging

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Proceedings Article | 7 March 2014 Paper

The study of hydrogen peroxide level under cisplatin action using genetically encoded sensor hyper

A. Belova, A. Orlova, A. Maslennikova, A. Brilkina, I. Balalaeva, N. Antonova, N. Mishina, N. Shakhova, V. Belousov

Proceedings Volume 8956, 895612 (2014) https://doi.org/10.1117/12.2037737

KEYWORDS: Luminescence, Hydrogen, Cell death, Sensors, Flow cytometry, Cervical cancer, Fluorescence spectroscopy, Tumors, Oxygen, Proteins

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SPIE Journal Paper | 1 July 2010 Open Access

In vivo study of photosensitizer pharmacokinetics by fluorescence transillumination imaging

Marina Shirmanova, Elena Zagainova, Marina Sirotkina, Ludmila Snopova, Irina Balalaeva, Irina Krutova, Nataliya Lekanova, Ilya Turchin, Anna Orlova, Mikhail Kleshnin

JBO, Vol. 15, Issue 04, 048004, (July 2010) https://doi.org/10.1117/12.10.1117/1.3478310

KEYWORDS: Tumors, Luminescence, In vivo imaging, Tissue optics, Tissues, Signal detection, Sensors, Calibration, Photodynamic therapy, Skin

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Proceedings Article | 12 February 2009 Paper

Multicolor frequency-domain diffuse optical tomography for detection of breast cancer

Anna Orlova, Vladislav Kamensky, German Yu. Golubiatnikov, Anna Maslennikova, Vladimir Plehanov, Natalia Shakhova, Mikhail Kleshnin, Ilya Turchin

Proceedings Volume 7174, 71741N (2009) https://doi.org/10.1117/12.807700

KEYWORDS: Tissues, Tumors, Breast, Absorption, Scattering, Oxygen, Diffuse optical tomography, Breast cancer, Light scattering, Tissue optics

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SPIE Journal Paper | 1 July 2008 Open Access

Fluorescence diffuse tomography for detection of red fluorescent protein expressed tumors in small animals

Ilya Turchin, Vladislav Kamensky, Vladimir Plehanov, Anna Orlova, Mikhail Kleshnin, Ilya Fiks, Marina Shirmanova, Irina Meerovich, Lyaisan Arslanbaeva, Viktoria Jerdeva, Alexander Savitsky

JBO, Vol. 13, Issue 04, 041310, (July 2008) https://doi.org/10.1117/12.10.1117/1.2953528

KEYWORDS: Luminescence, Tumors, Reconstruction algorithms, Sensors, Fluorescent proteins, Fluorescence tomography, Tomography, In vivo imaging, Absorption filters, 3D modeling

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Proceedings Article | 22 February 2008 Paper

Gold nanoshells for OCT imaging contrast: From model to in-vivo study

E. Zagaynova, M. Shirmanova, A. Orlova, I. Balalaeva, M. Yu. Kirillin, V. Kamensky, M. Bugrova, M. Sirotkina

Proceedings Volume 6865, 68650K (2008) https://doi.org/10.1117/12.763004

KEYWORDS: Optical coherence tomography, Skin, Gold, Monte Carlo methods, In vivo imaging, Nanoparticles, Optical properties, Scattering, Tissue optics, Computer simulations

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Proceedings Article | 27 July 2007 Paper

Observation of transparent objects by the method of nonlinear phase contrast

E. Bubis, V. Kamensky, A. Matveev, A. Orlova

Proceedings Volume 6729, 67291H (2007) https://doi.org/10.1117/12.752104

KEYWORDS: Image visualization, Visualization, Phase contrast, Liquids, Optical filters, Phase shifts, Quartz, Image processing, Phase shift keying, Spatial frequencies

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Proceedings Article | 13 July 2007 Paper

In vivo study of contrasting properties of gold nanoparticles for optical coherence tomography

E. Zagaynova, M. Shirmanova, A. Orlova, I. Balalaeva, M. Kirillin, V. Kamensky

Proceedings Volume 6633, 663316 (2007) https://doi.org/10.1117/12.728196

KEYWORDS: Skin, Nanoparticles, Optical coherence tomography, Monte Carlo methods, Gold, Particles, In vivo imaging, Optical properties, Scattering, Silica

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We have investigated the effect of application of gold nanoparticles with a diameter of 50 nm and nanoshells with a 150 nm silica core size and 25 nm thick gold shell on optical properties of skin. We have analyzed the possibility of using these particles as a contrasting agent for optical coherence tomography (OCT). As the first step in the study, effects of gold nanoparticles after one application to skin were studied using OCT. Then we evaluated the effects of multiple applications of 50 nm gold nanoparticles to skin in 30-minute intervals. Biopsy of relevant skin areas was performed under local anaesthesia and samples for light and electron microscopy were prepared. Identification of skin layers on OCT images was made by comparing with histology. Application of gold-silica nanoshells caused increase in intensity of useful signal, brightness of the superficial part of the dermis and contrast between the superficial and deep parts of the dermis 30 minutes after application on skin. After 24 hours the changes in OCT images became more pronounced as the brightness of the superficial part of the dermis and the contrast between the superficial and deep parts of the dermis further increased. In addition, the border between the superficial and deep parts of the dermis became more distinct, continuous and well discernible, permitting to accurately differentiate these layers. Besides that, the application of nanoshells caused contrasting of hair follicles and glands. In order to give interpretation to the obtained experimental OCT-images of skin and understand the mechanisms of contrasting a set of Monte Carlo calculations was performed in order to simulate the images of skin before and after application of the nanoparticles for skin model close to that in the experiment. The results of the simulation exhibit good qualitative agreement with the experimental images and prove that the contrasting originates from the nanoparticles added while contrasting of hair bulb originates from the absence of nanoparticles in it with their presence in surrounding area.

Proceedings Article | 11 July 2007 Paper

Fluorescence diffuse tomography for detection of RFP-expressed tumors in small animals

Ilya Turchin, Alexander Savitsky, Vladislav Kamensky, Vladimir Plehanov, Anna Orlova, Mikhail Kleshnin, Marina Shirmanova, Ilya Fix, Vladimir Popov

Proceedings Volume 6626, 66260R (2007) https://doi.org/10.1117/12.728470

KEYWORDS: Tumors, Luminescence, Sensors, 3D modeling, Point spread functions, Fluorescent proteins, Tomography, In vivo imaging, Reconstruction algorithms, Fluorescence tomography

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Proceedings Article | 7 May 2007 Paper

Fluorescence diffuse tomography for tumor detection and monitoring

Irina Balalaeva, Anna Orlova, Marina Shirmanova, Elena Kibraeva, Elena Zagainova, Ilya Turchin

Proceedings Volume 6535, 653509 (2007) https://doi.org/10.1117/12.740615

KEYWORDS: Tumors, Luminescence, Quantum dots, Fluorescent proteins, Proteins, Tomography, Tissues, Tissue optics, Cancer, Fluorescence tomography

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Proceedings Article | 1 May 2007 Paper

Frequency domain fluorescence diffuse tomography of small animals

Anna Orlova, Ilya Turchin, Vladislav Kamensky, Vladimir Plehanov, Irina Balalaeva, Ekaterina Sergeeva, Marina Shirmanova, Michail Kleshnin

Proceedings Volume 6534, 65343G (2007) https://doi.org/10.1117/12.741469

KEYWORDS: Luminescence, Tumors, Animal model studies, Scattering, Tomography, Sensors, Modulation, Glasses, Cancer, Diffusion

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Proceedings Article | 14 February 2007 Paper

Fluorescence diffuse tomography for detection of RFP-expressed tumors in small animals

Ilya Turchin, Alexander Savitsky, Vladislav Kamensky, Vladimir Plehanov, Irina Meerovich, Lyaisan Arslanbaeva, Viktoria Jerdeva, Anna Orlova, Mikhail Kleshnin, Marina Shirmanova, Ilya Fiks

Proceedings Volume 6449, 644915 (2007) https://doi.org/10.1117/12.714368

KEYWORDS: Tumors, Luminescence, 3D modeling, Point spread functions, Sensors, Fluorescent proteins, Tomography, In vivo imaging, Tissue optics, Scattering

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Proceedings Article | 22 February 2006 Paper

Combined use of optical coherence tomography and fluorescence cystoscopy to detect bladder neoplasia

Elena Zagaynova, Olga Streltsova, Anna Orlova, Natalia Shakhova, Natalia Gladkova, Ekaterina Unusova, Rashid Iksanov, Felix Feldchtein

Proceedings Volume 6078, 60781F (2006) https://doi.org/10.1117/12.645538

KEYWORDS: Optical coherence tomography, Cystoscopy, Luminescence, Bladder, Biopsy, Diagnostics, Tumors, Bladder cancer, Cancer, Endoscopy

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Proceedings Article | 22 February 2006 Paper

Frequency domain fluorescent diffuse tomography of small animals with DsRed2-expressed tumors

Ilya Turchin, Alexander Savitsky, Vladislav Kamensky, Vladimir Plehanov, Anna Orlova, Ekaterina Sergeeva, Mikhail Kleshnin, Marina Shirmanova

Proceedings Volume 6098, 60980C (2006) https://doi.org/10.1117/12.644565

KEYWORDS: Luminescence, Tumors, Tissues, Scattering, Tomography, Modulation, Fluorescent proteins, Signal detection, Sensors, Animal model studies

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Proceedings Article | 8 October 2005 Paper

Frequency-domain optical diffusion tomography of fluorescent proteins

Ilya Turchin, Vladimir Plehanov, Ekaterina Sergeeva, Anna Orlova, Vladimir Vorob'ev, Vladislav Kamensky, Alexander Savitsky

Proceedings Volume 5859, 58591H (2005) https://doi.org/10.1117/12.632879

KEYWORDS: Tumors, Fluorescent proteins, Tomography, Tissue optics, Modulation, Visualization, Animal model studies, Luminescence, Diffusion, Scattering

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