Tianyi Wang
Research Associate at
SPIE Involvement:
Author
Area of Expertise:
Thermal imaging , multi-photon luminescence microscopy (TPLM) , modeling of light and heat transfer in tissue , optical coherence tomography (OCT) , nanoparticle , medical image processing
Profile Summary

Currently a post-doctoral research associate working on cardiovascular disease detection in the Department of Biomedical Engineering at the University of Texas at Austin. Research area includes medical imaging system design, modeling and image processing, specifically in thermal imaging, optical coherence tomography, fluorescence imaging, modeling of light and heat transfer in tissue and medical image processing.

Project Experience:
6/2012-Present
Design of a Combined Fiber-based Two-photon Luminescence (TPL) and Optical Coherence Tomography (OCT) System and an Intravascular Imaging Catheter for Macrophage Detection in Atherosclerotic Plaques. A portable fiber-based TPL-OCT system with high power is designed and currently under instrumentation. Ray trace simulation is performed using Zemax to test macrophage imaging capability of the catheter compared to an ex vivo TPL microscope and to optimize the GRIN lens design in the catheter.

6/2009-5/2012
Macrophage and Lipid Detection in Atherosclerotic Plaques Using Gold Nanoparticles and Three Imaging Modalities: Optical Coherence Tomography (OCT), Photothermal Wave (PTW) Imaging and Two-photon Luminescence Microscopy (TPLM). Developed two hybrid imaging systems, PTW-OCT and TPLM-OCT, for atherosclerotic plaque detection. Specifically, PTW-OCT was utilized to visualize plaque-based macrophages and lipid deposits at multiple depths; TPLM-OCT was used to characterize the 3-D distribution of macrophages with respect to plaque surface profile at a higher resolution. The background subtraction algorithm was developed to enhance PTW images.

Awards:
3/2011 Graduate School Continuing Fellowship, University of Texas at Austin
2/2011 Best Student Paper Award, The American Society for Laser Medicine and Surgery (ASLMS)
1/2009 Research Excellence Award, The International Society for Optical Engineering (SPIE)
6/2005 Outstanding Graduate, Wuhan University
Publications (12)

SPIE Journal Paper | November 5, 2015
JBO Vol. 20 Issue 11
KEYWORDS: Light scattering, Scattering, CMOS sensors, Control systems, Polarization, Tissues, NOx, Refractive index, Cancer, In vitro testing

SPIE Journal Paper | December 29, 2014
JBO Vol. 19 Issue 12
KEYWORDS: Blood, Optical coherence tomography, Light scattering, Scattering, 3D image reconstruction, 3D image processing, Contamination, Image acquisition, Statistical analysis, In vitro testing

SPIE Journal Paper | March 27, 2012
JBO Vol. 17 Issue 03
KEYWORDS: Optical coherence tomography, Image segmentation, Modulation, Nanoparticles, Luminescence, Optical imaging, Microscopy, Laser irradiation, Absorption, Gold

SPIE Journal Paper | March 7, 2012
JBO Vol. 17 Issue 02
KEYWORDS: Nanoparticles, Gold, Luminescence, Iron, Oxides, Coating, Confocal microscopy, Particles, Transmission electron microscopy, Molecules

PROCEEDINGS ARTICLE | January 30, 2012
Proc. SPIE. 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
KEYWORDS: Eye, Polarization, Birefringence, Nerve, Imaging systems, Optical coherence tomography, Computing systems, Diagnostics, Field programmable gate arrays, Tissue optics

SPIE Journal Paper | July 1, 2011
JBO Vol. 16 Issue 07
KEYWORDS: Sclera, Blood vessels, Optical properties, Blood, Absorption, Scattering, Eye, Tissue optics, Tissues, Phase modulation

Showing 5 of 12 publications
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