Mr. Zhikai L. Zhu Profile

Zhikai L. Zhu

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Publications (17)

Proceedings Article | 3 April 2024 Paper

Fast endoscopic OCTA imaging in mouse rectum using proximal scanning catheter

Chen Niu, Zehua Guan, Wenjuan Wu, Zhikai Zhu, Cuixia Dai

Proceedings Volume 12830, 128300E (2024) https://doi.org/10.1117/12.3002068

KEYWORDS: Endoscopy, Optical coherence tomography, Rectum, Tissues, Biological imaging, Imaging systems, Image registration, Biological samples, Reflection, Data acquisition

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In recent years, endoscopic optical coherence tomography (OCT) has garnered widespread attention for non-invasive advantages in achieving three-dimensional visualization of internal organ cavities. In early-stage lesions, microvascular alterations occur before morphological tissue changes. Therefore, utilizing endoscopic OCTA for the detection of superficial capillaries serves as an adjunctive method for early disease screening. About ten years ago, the advantages of high-speed and stable operation of distal motorized catheters enabled the realization of endoscopic OCTA. However, the internal micro-motors lead to a larger outer diameter of distal imaging catheters, which restricts their clinical applicability for monitoring diseases in narrow luminal structures. Consequently, proximal imaging catheters, with their smaller size, have found its wide application in the commercial arena. However, due to limitations in external motor speed and susceptibility to external vibrations, there were no reports of proximal imaging catheters achieving endoscopic OCTA for a long time. Recently, we proposed the MB-scan scheme to mitigate the impact of external motion artifacts and achieve endoscopic OCTA based on a proximal catheter. The Singular Value Decomposition (SVD) algorithm was employed to eliminate static tissue information and obtain en face OCTA images of the murine rectum. In this study, we proposed a fast endoscopic OCTA using proximal scanning catheter based on B-scan scheme and a customed image registration algorithm. Image registration based on the similarity between adjacent B-scan frames was utilized to reduce the impact of external motor vibrations and improve image quality. Based on the registered images at the same scanning position, the speckle variance (SVAR) algorithm was employed to calculate variation of OCT intensity signals. Finally, en face OCTA images were generated. Collecting data from the mouse rectum, endoscopic OCTA images were obtained from the registered data using the SVAR algorithm.

Proceedings Article | 13 March 2024 Poster

Optical coherence elastography of the cornea after electromechanical reshaping

Katelyn Dilley, Daniel Kim, Lauren Liu, Fengyi Zhang, Wei Jin, Zhikai Zhu, Ellen Hong, Zhongping Chen, Michael Hill, Brian J. Wong

Proceedings Volume PC12824, PC128241V (2024) https://doi.org/10.1117/12.3008909

KEYWORDS: Cornea, Optical coherence, Elastography, Optical coherence tomography, In vivo imaging, Acoustics, Wave propagation, Ultrasound transducers, Tissues, Shape analysis

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Proceedings Article | 13 March 2024 Presentation

Endoscope OCT for 3D imaging of sleep apnea patient's airway and airflow dynamics

Zhikai Zhu, Hongqiu Lei, Li-Dek Chou, Theodore Nguyen, Katelyn Dilley, Ellen Hong, Brian J. Wong, Douglas Trask, Zhongping Chen

Proceedings Volume PC12818, (2024) https://doi.org/10.1117/12.3003605

KEYWORDS: Sleep apnea, Optical coherence tomography, Endoscopes, Stereoscopy, 3D modeling, Diseases and disorders, Diagnostics, Biological imaging, Visualization, Turbulence

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Proceedings Article | 13 March 2024 Presentation

Multimodal imaging of ciliary dynamics using optical coherence tomography and phase-resolved spectrally encoded interferometric microscopy

Wenqi He, Do Kim, Zhikai Zhu, Lidek Chou, Katelyn Dilley, Ellen Hong, Edward Kuan, Brian Wong, Zhongping Chen

Proceedings Volume PC12818, (2024) https://doi.org/10.1117/12.3001959

KEYWORDS: Phase interferometry, Optical coherence tomography, Microscopy, Multimodal imaging, Visualization, Visual analytics, Pulmonary disorders, Motion analysis, Laser sources, Laser frequency

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Proceedings Article | 17 March 2023 Poster

Quantitative elastography of the optic nerve head using shaker-based optical coherence tomography

Fengyi Zhang, Runze Li, Yan Li, Zhikai Zhu, Qifa Zhou, Zhongping Chen

Proceedings Volume PC12360, PC123601F (2023) https://doi.org/10.1117/12.2651323

KEYWORDS: Optic nerve, Head, Elastography, Optical coherence tomography, In vivo imaging, Retina, Eye, Surgery, Retinal scanning, Coherence (optics)

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Proceedings Article | 17 March 2023 Presentation

Deep learning accelerated quantitative assessment for optical coherence tomography images of acute chlorine gas inhalation injury in a rabbit model

Zhikai Zhu, Hongqiu Lei, Raksha Sreeramachandra Murthy, Theodore Nguyen, Katelyn Dilley, Donggyoon Hong, Xiao Gao, Matthew Brenner, Zhongping Chen

Proceedings Volume 12354, 123540M (2023) https://doi.org/10.1117/12.2668720

KEYWORDS: Optical coherence tomography, Chlorine gas, Injuries, Deep learning, In vivo imaging, Chlorine, Nervous system, Ultrasonography, Tomography, Spatial resolution

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Proceedings Article | 14 March 2023 Presentation + Paper

The effects of epinephrine on ciliary beat frequency in human sinonasal mucosa

Katelyn Dilley, Theodore Nguyen, Do Kim, Lidek Chou, Zhikai Zhu, Donggyoon Hong, Milind Vasudev, Zhongping Chen, Edward Kuan, Brian J. Wong

Proceedings Volume 12354, 123540L (2023) https://doi.org/10.1117/12.2670003

KEYWORDS: Microscopy, Diseases and disorders, Imaging systems, Data analysis

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Proceedings Article | 14 March 2023 Presentation + Paper

High-speed imaging of cilia beat frequency using phase-resolved spectrally encoded interferometric microscopy

Do Kim, Zhikai Zhu, Lidek Chou, Katelyn Dilley, Theodore Nguyen, Edward Kuan, Brian Wong, Zhongping Chen

Proceedings Volume 12354, 1235407 (2023) https://doi.org/10.1117/12.2651305

KEYWORDS: Phase interferometry, Microscopy, In vivo imaging, Tissues, High speed imaging, GRIN lenses, Endoscopy, Surgery, Optical coherence tomography, Laser interferometry

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Proceedings Article | 9 March 2022 Presentation + Paper

Validation of spectrally encoded interferometric microscopy (SEIM) in finding ciliary beat frequency of human ex vivo upper airway tissue

Asher Park, Zhikai Zhu, Lidek Chou, Katelyn Dilley, Akarsh Lal, Edward Kuan, Zhongping Chen, Brian J. Wong

Proceedings Volume 11935, 1193505 (2022) https://doi.org/10.1117/12.2607390

KEYWORDS: Tissues, Microscopy, Interferometry, In vivo imaging, Natural surfaces, Optical coherence tomography, Imaging systems, Chromium, Video, Surgery

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Proceedings Article | 7 March 2022 Presentation

Homemade prototype nasal probe for spectrally encoded interferometric microscopy (SEIM)

Zhikai Zhu, Lidek Chou, Asher Park, Brian J. Wong, Zhongping Chen

Proceedings Volume PC11935, PC1193504 (2022) https://doi.org/10.1117/12.2609068

KEYWORDS: Prototyping, Microscopy, Interferometry, Vertical cavity surface emitting lasers, Imaging systems, Chromium, Algorithm development, Real time imaging, Pathogens, Optical coherence tomography

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Proceedings Article | 7 March 2022 Presentation

In-vivo airway compliance analysis of acute chlorine gas inhalation injury in rabbit model

Zhikai Zhu, George Philipopoulos, Melody Doosty, Jangwoen Lee, David Mukai, Xiao Gao, Sari Mahon, Matthew Brenner, Livia Veress, Carl White, Zhongping Chen

Proceedings Volume PC11937, PC119370E (2022) https://doi.org/10.1117/12.2610423

KEYWORDS: In vivo imaging, Injuries, Chlorine gas, Imaging systems, Vertical cavity surface emitting lasers, Optical coherence tomography, Tissues, Pathogens, Light sources, Image segmentation

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Proceedings Article | 5 March 2021 Presentation

In-vivo analysis of acute chlorine gas inhalation injury using optical coherence tomography (OCT) in rabbit model

Zhikai Zhu, Yusi Miao, George Philipopoulos, Melody Doosty, Wenqi He, Jianing Tang, Jangwoen Lee, David Mukai, Fengyi Zhang, Saijun Qiu, Jing Cao, Xiao Gao, Sari Mahon, Livia Veress, Matthew Brenner, Carl White, Zhongping Chen

Proceedings Volume 11620, 1162007 (2021) https://doi.org/10.1117/12.2577927

KEYWORDS: Optical coherence tomography, Injuries, Chlorine gas, In vivo imaging, Tissues, Imaging systems, Vertical cavity surface emitting lasers, Bronchoscopy, Visualization, Diagnostics

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Proceedings Article | 5 March 2021 Presentation

Wide-field mapping of upper airway cilia dynamics using spectrally encoded interferometric microscopy

Zhikai Zhu, Jason Chen, Yusi Miao, David Mukai, George Philipopoulos, Melina Doosty, Jangwoen Lee, Sari Mahon, Matthew Brenner, Brian J. Wong, Zhongping Chen

Proceedings Volume 11627, 1162708 (2021) https://doi.org/10.1117/12.2578007

KEYWORDS: Microscopy, Interferometry, Doppler effect, Visualization, Wave propagation, Viruses, Spatial resolution, Pathogens, Particles, Optical imaging

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Proceedings Article | 5 March 2021 Presentation

Ultrahigh sensitive optical coherence elastography

Yan Li, Sucbei Moon, Jason Chen, Zhikai Zhu, Zhongping Chen

Proceedings Volume 11645, 116450I (2021) https://doi.org/10.1117/12.2576433

KEYWORDS: Elastography, Coherence (optics), Signal to noise ratio, Optical coherence tomography, Tissues, Signal generators, Precision measurement, Polarization, Photodetectors, Performance modeling

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Proceedings Article | 5 March 2021 Presentation

Novel polarization-sensitive optical coherence tomography based on spun fiber to study articular cartilage degenerative processing

Saijun Qiu, Sucbei Moon, Xiaoqin Zhu, Zhikai Zhu, Zhongping Chen

Proceedings Volume 11646, 116460X (2021) https://doi.org/10.1117/12.2577910

KEYWORDS: Cartilage, Optical coherence tomography, Polarization, Birefringence, Imaging systems, Collagen, Tissue optics, Diagnostics, Biological research

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Proceedings Article | 9 March 2020 Presentation

Multimodal endoscopy for colorectal cancer detection by optical coherence tomography and near-infrared fluorescence imaging (Conference Presentation)

Yan Li, Zhikai Zhu, Jason Chen, Joseph Jing, Zhongping Chen

Proceedings Volume 11232, 112320F (2020) https://doi.org/10.1117/12.2542964

KEYWORDS: Optical coherence tomography, Luminescence, Colorectal cancer, Endoscopy, Near infrared, Imaging systems, Error control coding, Multimodal imaging, Cancer, Indocyanine green

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Proceedings Article | 4 March 2019 Presentation

High speed in vivo endoscopic photoacoustic and ultrasound dual-modality imaging (Conference Presentation)

Yan Li, Zhikai Zhou, Joseph Jing, Emon Heidari, Youmin He, Jiang Zhu, Teng Ma, Mingyue Yu, Qifa Zhou, Zhongping Chen

Proceedings Volume 10854, 108540D (2019) https://doi.org/10.1117/12.2505747

KEYWORDS: Imaging systems, Endoscopy, In vivo imaging, Photoacoustic spectroscopy, Ultrasonography, Cancer, Colorectal cancer, Photoacoustic imaging, Pulsed laser operation, Laser tissue interaction

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Showing 5 of 17 publications

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