Dr. Yunjie Tong Profile

Dr. Yunjie Tong

Assistant Professor at Purdue Univ

SPIE Involvement:

Author

Publications (20)

SPIE Journal Paper | 30 August 2022 Open Access

Open Access

Optical imaging and spectroscopy for the study of the human brain: status report

Hasan Ayaz, Wesley Baker, Giles Blaney, David Boas, Heather Bortfeld, Kenneth Brady, Joshua Brake, Sabrina Brigadoi, Erin M. Buckley, Stefan Carp, Robert Cooper, Kyle Cowdrick, Joseph Culver, Ippeita Dan, Hamid Dehghani, Anna Devor, Turgut Durduran, Adam Eggebrecht, Lauren Emberson, Qianqian Fang, Sergio Fantini, Maria Angela Franceschini, Jonas Fischer, Judit Gervain, Joy Hirsch, Keum-Shik Hong, Roarke Horstmeyer, Jana Kainerstorfer, Tiffany Ko, Daniel Licht, Adam Liebert, Robert Luke, Jennifer Lynch, Jaume Mesquida, Rickson Mesquita, Noman Naseer, Sergio Novi, Felipe Orihuela-Espina, Thomas O'Sullivan, Darcy Peterka, Antonio Pifferi, Luca Pollonini, Angelo Sassaroli, João Ricardo Sato, Felix Scholkmann, Lorenzo Spinelli, Vivek Srinivasan, Keith St. Lawrence, Ilias Tachtsidis, Yunjie Tong, Alessandro Torricelli, Tara Urner, Heidrun Wabnitz, Martin Wolf, Ursula Wolf, Shiqi Xu, Changhuei Yang, Arjun Yodh, Meryem Yücel, Wenjun Zhou

NPh, Vol. 9, Issue S2, S24001, (August 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.S2.S24001

KEYWORDS: Brain, Near infrared spectroscopy, Neuroimaging, Imaging spectroscopy, Sensors, Optical imaging, Optical spectroscopy imaging, Optical spectroscopy, Spectroscopy, Tissue optics

Read Abstract +

SPIE Journal Paper | 8 February 2021 Open Access

Open Access

Errata: Best practices for fNIRS publications

Meryem Yücel, Alexander von Lühmann, Felix Scholkmann, Judit Gervain, Ippeita Dan, Hasan Ayaz, David Boas, Robert J. Cooper, Joseph Culver, Clare Elwell, Adam Eggebrecht, Maria Angela Franceschini, Christophe Grova, Fumitaka Homae, Frédéric Lesage, Hellmuth Obrig, Ilias Tachtsidis, Sungho Tak, Yunjie Tong, Alessandro Torricelli, Heidrun Wabnitz, Martin Wolf

NPh, Vol. 8, Issue 01, 019802, (February 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.1.019802

KEYWORDS: Biomedical engineering, Medical research, Neurophotonics, Analytical research, Radiology, Medicine, Biomedical optics, Psychology, Medical physics, Functional imaging

Read Abstract +

SPIE Journal Paper | 7 January 2021 Open Access

Open Access

Best practices for fNIRS publications

Meryem Yücel, Alexander Lühmann, Felix Scholkmann, Judit Gervain, Ippeita Dan, Hasan Ayaz, David Boas, Robert Cooper, Joseph Culver, Clare Elwell, Adam Eggebrecht, Maria Franceschini, Christophe Grova, Fumitaka Homae, Frédéric Lesage, Hellmuth Obrig, Ilias Tachtsidis, Sungho Tak, Yunjie Tong, Alessandro Torricelli, Heidrun Wabnitz, Martin Wolf

NPh, Vol. 8, Issue 01, 012101, (January 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.1.012101

KEYWORDS: Statistical analysis, Brain, Signal processing, Neurophotonics, Sensors, Hemodynamics, Tissues, Standards development, Head, Visualization

Read Abstract +

SPIE Journal Paper | 19 June 2020 Open Access

Open Access

Asymmetry of peripheral vascular biomarkers in ischemic stroke patients, assessed using NIRS

Yingwei Li, Yunfei Ma, Shaoqing Ma, Zhenhu Liang, Fang Xu, Yunjie Tong, Blaise deB. Frederick, Shimin Yin, Xiaoli Li

JBO, Vol. 25, Issue 06, 065001, (June 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.6.065001

KEYWORDS: Ischemic stroke, Near infrared spectroscopy, Arteries, Blood, Blood circulation, Ear, Fuzzy logic, Oximeters, Brain, Oxygen

Read Abstract +

Significance: Low-frequency oscillations (LFOs) ranging from 0.01 to 0.15 Hz are common in functional imaging studies. Some of these LFOs are non-neuronal and are correlated with autonomic physiological processes. Aim: We investigate the relationships between systemic low-frequency oscillations (sLFOs) measured at different peripheral sites during resting states in ischemic stroke patients. Approach: Twenty-seven ischemic stroke patients (ages 44 to 90; 20 male and 7 female) were recruited for the study. During the experiments, fluctuations in oxyhemoglobin concentration were measured in the left and right toes, fingertips, and earlobes using a multichannel near-infrared spectroscopy instrument. We applied cross-correlation and frequency component analyses on the sLFO data. Results: The results showed that embolization broke the symmetry of the sLFO transmission and that the damage was not limited to the local area but spread throughout the body. Among six peripheral sites, the power spectrum width of the earlobes was significantly larger than that of the fingers and toes. This indicates that the earlobes may contain more physiological information. Finally, the results of fuzzy clustering verified that sLFOs can serve as perfusion biomarkers to differentiate stroke from healthy subjects. Conclusions: The high correlation values and corresponding delays in sLFOs support the hypothesis that (1) the correlation characteristics of sLFOs in stroke patients are different from those of healthy subjects. These characteristics can reflect patient condition, to an extent. Embolization in ischemic stroke patients breaks the symmetry of the body’s sLFO transmission, disrupting the balance of blood circulation. (2) sLFOs can be used as perfusion biomarkers to differentiate ischemic stroke patients from healthy subjects. Studying these signals can explicate the overall feedback/influence of pericentral interactions. Finally, peripheral sLFOs have been shown to be an effective and accurate tool for assessing peripheral blood circulation and vascular integrity in ischemic stroke patients.

SPIE Journal Paper | 9 January 2019 Open Access

Open Access

Denoising of neuronal signal from mixed systemic low-frequency oscillation using peripheral measurement as noise regressor in near-infrared imaging

Stephanie Sutoko, Yee Ling Chan, Akiko Obata, Hiroki Sato, Atsushi Maki, Takashi Numata, Tsukasa Funane, Hirokazu Atsumori, Masashi Kiguchi, Tong Boon Tang, Yingwei Li, Blaise deB. Frederick, Yunjie Tong

NPh, Vol. 6, Issue 01, 015001, (January 2019) https://doi.org/10.1117/12.10.1117/1.NPh.6.1.015001

KEYWORDS: Denoising, Interference (communication), Ear, Principal component analysis, Brain, Control systems, Neurophotonics, Remote sensing, Imaging systems, Computer programming

Read Abstract +

Functional near-infrared spectroscopy (fNIRS) is a noninvasive functional imaging technique measuring hemodynamic changes including oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin. Low frequency (LF; 0.01 to 0.15 Hz) band is commonly analyzed in fNIRS to represent neuronal activation. However, systemic physiological artifacts (i.e., nonneuronal) likely occur also in overlapping frequency bands. We measured peripheral photoplethysmogram (PPG) signal concurrently with fNIRS (at prefrontal region) to extract the low-frequency oscillations (LFOs) as systemic noise regressors. We investigated three main points in this study: (1) the relationship between prefrontal fNIRS and peripheral PPG signals; (2) the denoising potential using these peripheral LFOs, and (3) the innovative ways to avoid the false-positive result in fNIRS studies. We employed spatial working memory (WM) and control tasks (e.g., resting state) to illustrate these points. Our results showed: (1) correlation between signals from prefrontal fNIRS and peripheral PPG is region-dependent. The high correlation with peripheral ear signal (i.e., O2Hb) occurred mainly in frontopolar regions in both spatial WM and control tasks. This may indicate the finding of task-dependent effect even in peripheral signals. We also found that the PPG recording at the ear has a high correlation with prefrontal fNIRS signal than the finger signals. (2) The systemic noise was reduced by 25% to 34% on average across regions, with a maximum of 39% to 58% in the highly correlated frontopolar region, by using these peripheral LFOs as noise regressors. (3) By performing the control tasks, we confirmed that the statistically significant activation was observed in the spatial WM task, not in the controls. This suggested that systemic (and any other) noises unlikely violated the major statistical inference. (4) Lastly, by denoising using the task-related signals, the significant activation of region-of-interest was still observed suggesting the manifest task-evoked response in the spatial WM task.

SPIE Journal Paper | 4 May 2018 Open Access

Open Access

Systemic low-frequency oscillations observed in the periphery of healthy human subjects

Yingwei Li, Haibing Zhang, Meiling Yu, Weiwei Yu, Blaise deB. Frederick, Yunjie Tong

JBO, Vol. 23, Issue 05, 057001, (May 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.5.057001

KEYWORDS: Near infrared spectroscopy, Remote sensing, Blood, Signal detection, Oximeters, Human subjects, Modulation, Heart, Arteries, Brain

Read Abstract +

SPIE Journal Paper | 5 October 2016 Open Access

Open Access

Design of multichannel functional near-infrared spectroscopy system with application to propofol and sevoflurane anesthesia monitoring

Zhenhu Liang, Yue Gu, Xuejing Duan, Lei Cheng, Shujuan Liang, Yunjie Tong, Xiaoli Li

NPh, Vol. 3, Issue 04, 045001, (October 2016) https://doi.org/10.1117/12.10.1117/1.NPh.3.4.045001

KEYWORDS: Hemodynamics, Near infrared spectroscopy, Brain, Near infrared, Imaging systems, Multichannel imaging systems, Neurophotonics, Surgery, Sensors, Consciousness

Read Abstract +

SPIE Journal Paper | 10 December 2015 Open Access

Open Access

Optimized multimodal functional magnetic resonance imaging/near-infrared spectroscopy probe for ultrahigh-resolution mapping

Lia Maria Hocke, Kenroy Cayetano, Yunjie Tong, Blaise Frederick

NPh, Vol. 2, Issue 04, 045004, (December 2015) https://doi.org/10.1117/12.10.1117/1.NPh.2.4.045004

KEYWORDS: Functional magnetic resonance imaging, Sensors, Signal to noise ratio, Head, Magnetic resonance imaging, Near infrared spectroscopy, Spatial resolution, Temporal resolution, Data acquisition, 3D printing

Read Abstract +

SPIE Journal Paper | 1 October 2012 Open Access

Open Access

Low-frequency oscillations measured in the periphery with near-infrared spectroscopy are strongly correlated with blood oxygen level-dependent functional magnetic resonance imaging signals

Yunjie Tong, Lia Maria Hocke, Stephanie Licata, Blaise Frederick

JBO, Vol. 17, Issue 10, 106004, (October 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.10.106004

KEYWORDS: Near infrared spectroscopy, Functional magnetic resonance imaging, Brain, Blood, Oxygen, MATLAB, Optical fibers, Video, Brain mapping, Bandpass filters

Read Abstract +

SPIE Journal Paper | 1 October 2011 Open Access

Open Access

Isolating the sources of widespread physiological fluctuations in functional near-infrared spectroscopy signals

Yunjie Tong, Lia Maria Hocke, Blaise Frederick

JBO, Vol. 16, Issue 10, 106005, (October 2011) https://doi.org/10.1117/12.10.1117/1.3638128

KEYWORDS: Functional magnetic resonance imaging, Brain, Signal detection, Blood, Veins, Near infrared spectroscopy, Head, Sensors, Neuroimaging, Capillaries

Read Abstract +

Proceedings Article | 17 February 2011 Paper

Paper

Mapping cerebrovascular reactivity using concurrent fMRI and near infrared spectroscopy

Yunjie Tong, Peter Bergethon, Blaise Frederick

Proceedings Volume 7896, 789605 (2011) https://doi.org/10.1117/12.875028

KEYWORDS: Near infrared spectroscopy, Functional magnetic resonance imaging, Remote sensing, Brain, Brain mapping, Carbon dioxide, Data acquisition, Blood, Hemodynamics, Magnetic resonance imaging

Read Abstract +

Proceedings Article | 12 February 2008 Paper

Paper

Data analysis and statistical tests for near-infrared functional studies of the brain

Angelo Sassaroli, Yunjie Tong, Christian Benes, Sergio Fantini

Proceedings Volume 6850, 685008 (2008) https://doi.org/10.1117/12.761707

KEYWORDS: Brain, Data analysis, Computer simulations, Data processing, Error analysis, Optical fibers, Functional near infrared spectroscopy, Near infrared spectroscopy, Hemodynamics, Brain activation

Read Abstract +

Proceedings Article | 7 May 2007 Paper

Paper

Concurrent NIRS-fMRI activation studies by using a new method for BOLD signal analysis

Angelo Sassaroli, Bruce Frederick, Yunjie Tong, Perry Renshaw, Sergio Fantini

Proceedings Volume 6535, 65350F (2007) https://doi.org/10.1117/12.740637

KEYWORDS: Near infrared spectroscopy, Functional magnetic resonance imaging, Brain, Channel projecting optics, Head, Neuroimaging, Tissues, Signal analysis, Hemodynamics, Tissue optics

Read Abstract +

Proceedings Article | 8 February 2007 Paper

Paper

Fast optical response to electrical activation in peripheral nerves

Debbie Chen, Yunjie Tong, Angelo Sassaroli, Peter Bergethon, Sergio Fantini

Proceedings Volume 6431, 643104 (2007) https://doi.org/10.1117/12.698650

KEYWORDS: Nerve, Electrodes, Tissue optics, Biomedical optics, Near infrared spectroscopy, Brain, Optical testing, Nervous system, Hemodynamics, Skull

Read Abstract +

SPIE Journal Paper | 1 July 2006 Open Access

Open Access

Fast optical signals in the peripheral nervous system

Yunjie Tong, Jeffrey Martin, Angelo Sassaroli, Patricia Clervil, Peter Bergethon, Sergio Fantini

JBO, Vol. 11, Issue 04, 044014, (July 2006) https://doi.org/10.1117/12.10.1117/1.2234319

KEYWORDS: Tissue optics, Nerve, Nervous system, Scattering, Absorption, Hemodynamics, Optical testing, Near infrared spectroscopy, Signal detection, Biomedical optics

Read Abstract +

Proceedings Article | 13 February 2006 Paper

Paper

Comparison of optical imaging and functional magnetic resonance imaging of the human brain using a photon-hitting density weight in the calculation of the BOLD signal

Angelo Sassaroli, Bruce Frederick, Yunjie Tong, Perry Renshaw, Sergio Fantini

Proceedings Volume 6081, 60810C (2006) https://doi.org/10.1117/12.659692

KEYWORDS: Near infrared spectroscopy, Functional magnetic resonance imaging, Brain, Brain mapping, Hemodynamics, Head, Optical imaging, Neuroimaging, Tissue optics, Tissues

Read Abstract +

Proceedings Article | 28 April 2005 Paper

Paper

Studying brain function with near-infrared spectroscopy concurrently with electroencephalography

Y. Tong, E. Rooney, P. Bergethon, J. Martin, A. Sassaroli, B. Ehrenberg, Vo Van Toi, P. Aggarwal, N. Ambady, S. Fantini

Proceedings Volume 5693, (2005) https://doi.org/10.1117/12.587662

KEYWORDS: Electroencephalography, Near infrared spectroscopy, Hemodynamics, Brain, Sensors, Optical fibers, Electrodes, Neuroimaging, Data acquisition, Tissue optics

Read Abstract +

Proceedings Article | 28 April 2005 Paper

Paper

Studying brain function with concurrent near-infrared spectroscopy (NIRS) and functional magnetic resonance imaging (fMRI)

A. Sassaroli, Y. Tong, B. Frederick, P. Renshaw, B. Ehrenberg, S. Fantini

Proceedings Volume 5693, (2005) https://doi.org/10.1117/12.588422

KEYWORDS: Functional magnetic resonance imaging, Optical fibers, Near infrared spectroscopy, Sensors, Brain, Head, Laser sources, Neuroimaging, Human subjects, Photomultipliers

Read Abstract +

Proceedings Article | 13 July 2004 Paper

Paper

Functional mapping of the human brain with near-infrared spectroscopy in the frequency-domain

Angelo Sassaroli, Yunjie Tong, Francesco Fabbri, Blaise Frederick, Perry Renshaw, Sergio Fantini

Proceedings Volume 5312, (2004) https://doi.org/10.1117/12.533168

KEYWORDS: Sensors, Absorption, Optical spheres, Tissue optics, Brain, Monte Carlo methods, Spherical lenses, Signal detection, Brain mapping, Brain activation

Read Abstract +

Proceedings Article | 15 May 2002 Paper

Paper

High-resolution spectral self-interference fluorescence microscopy

Anna Swan, Lev Moiseev, Yunjie Tong, Samuel Lipoff, William Karl, Bennett Goldberg, M. Selim Unlu

Proceedings Volume 4621, (2002) https://doi.org/10.1117/12.467834

KEYWORDS: Luminescence, Microscopy, Silicon, Mirrors, Image resolution, Data modeling, Spectral resolution, Objectives, Dielectrics, Microscopes

Read Abstract +

Showing 5 of 20 publications

SIGN IN TO:

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Advertisement

Advertisement