Dr. Jennifer K. Barton Profile

Dr. Jennifer K. Barton

Professor, Biomedical Engineering at Univ of Arizona

SPIE Involvement:

| Board of Directors | Corporate and Exhibitor Committee | Engineering, Science, and Technology Policy Committee | Membership & Communities Committee | Nominating Committee | Strategic Planning Committee | Fellow status | Conference Program Committee | Author

Websites:

Company Website

Publications (100)

PROCEEDINGS ARTICLE | June 5, 2018

Design, manufacturing and opto-mechanical considerations for multimodal micro-endoscope featuring optical coherence microscopy, multiphoton microscopy and visible navigation

Proc. SPIE. 10690, Optical Design and Engineering VII

KEYWORDS: Optical components, Diffraction, Optical design, Imaging systems, Manufacturing, Zinc, Endoscopes, Tissue optics, Optics manufacturing, Miniature imaging systems

Complex endoscopes which utilize optics with less than 1.5 mm diameter have an elevated risk of failure. Therefore, to ensure functionality and minimize risk proper design, optomechanical analysis and modelling must be performed while taking into consideration current manufacturing capabilities. Our endoscope is designed to perform Optical Coherence and Multiphoton Microscopy (OCM and MPM) which are powerful endoscopic imaging techniques used to characterize tissue. Separately each imaging technique has limitations when used by itself; however, this design combines these two modalities into a single optical system to work in synergy achieving both high sensitivity and specificity for diagnosis at the point of care. The optical design features two optical paths with different numerical apertures (NA) through a single lens system with a scanning optical fiber. The dual path is achieved using dichroic coatings embedded in a triplet that functions in a telescope like fashion. A high NA ~0.44 path is designed to perform OCM and MPM while a low NA ~.18 path is designed for the visible spectrum to allow navigation of the endoscope to areas of interest. We present the optical design of the endoscope, optomechanical considerations, manufacturability, stress and temperature effects. All these factors may be a source of problems in such small optics utilizing rare materials such as ZnS MS lenses. While very tight tolerances were the driving factor for the manufacturability of this system, temperature and stress must also be evaluated to obtain a better idea of the durability of the endoscope at the point of care. While it is challenging to evaluate the real performance of multimodality endoscopes, the models ensure that the system is designed for the expected imaging techniques, providing acceptable imaging across the entire field of view. Finally, we will give insight on what lessons were learned during the design, analysis, lens manufacturing, and assembling processes of the endoscope to provide a baseline of parameters to take into consideration when designing such complex small optical systems.

PROCEEDINGS ARTICLE | February 20, 2018

Proximal design for a multimodality endoscope with multiphoton microscopy, optical coherence microscopy and visual modalities

Proc. SPIE. 10501, Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics

KEYWORDS: Optical filters, Mirrors, Second-harmonic generation, Multiphoton microscopy, Sensors, Spectroscopy, Wavelength division multiplexing, Endoscopes, Fiber couplers, Signal detection

PROCEEDINGS ARTICLE | February 14, 2018

Full optical model of micro-endoscope with optical coherence microscopy, multiphoton microscopy and visible capabilities

Proc. SPIE. 10470, Endoscopic Microscopy XIII

KEYWORDS: Multimodal imaging, Imaging systems, Sensors, Reflectivity, 3D modeling, Endoscopes, Navigation systems, Geometrical optics, Tissue optics, Systems modeling

PROCEEDINGS ARTICLE | February 12, 2018

Structural and functional assessment of intense therapeutic ultrasound effects on partial Achilles tendon transection

Proc. SPIE. 10484, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI

KEYWORDS: Birefringence, Visualization, Tissues, Surgery, Ultrasonography, Optical coherence tomography, Skin, Collagen, Inflammation, Animal model studies

PROCEEDINGS ARTICLE | February 7, 2018

Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

Proc. SPIE. 10472, Diagnosis and Treatment of Diseases in the Breast and Reproductive System IV

KEYWORDS: Image processing algorithms and systems, Tissues, Speckle, Optical coherence tomography, Image segmentation, Image processing, Digital filtering, Gaussian filters, Ovarian cancer, Ovary

PROCEEDINGS ARTICLE | January 25, 2018

Performance of combined OCT/MFI microendoscope for ovarian cancer detection

Proc. SPIE. 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III

SPIE Journal Paper | October 2, 2017

Wavelength-coded volume holographic imaging endoscope for multidepth imaging

Howlett, Isela , Han, Wanglei , Rice, Photini , Barton, Jennifer , Kostuk, Raymond

JBO Vol. 22 Issue 10

KEYWORDS: Holograms, Endoscopes, Holography, Imaging systems, Volume holography, Image resolution, Tissue optics, Light emitting diodes, Multiplexing, Dispersion

SPIE Journal Paper | May 31, 2017

Volume holographic imaging endoscopic design and construction techniques

Howlett, Isela , Han, Wanglei , Gordon, Michael , Rice, Photini , Barton, Jennifer , Kostuk, Raymond

JBO Vol. 22 Issue 05

KEYWORDS: Holography, Optical design, Imaging systems, Tissues, Endoscopy, Laparoscopy, Relays, Tissue optics, GRIN lenses, Reflectivity

SPIE Journal Paper | March 23, 2017

Ultraminiature optical design for multispectral fluorescence imaging endoscopes

Tate, Tyler , Keenan, Molly , Black, John , Utzinger, Urs , Barton, Jennifer

JBO Vol. 22 Issue 03

KEYWORDS: Luminescence, Endoscopes, Imaging systems, Image filtering, Multispectral imaging, Ultraviolet radiation, Optical design, Optical filters, Reflectivity, Fallopian tube

PROCEEDINGS ARTICLE | February 15, 2017

Single lens system for forward-viewing navigation and scanning side-viewing optical coherence tomography

Proc. SPIE. 10040, Endoscopic Microscopy XII

KEYWORDS: GRIN lenses, Optical design, Cancer, Reflection, Optical coherence tomography, Reflectivity, Lens design, Endoscopes, Cardiovascular system, Navigation systems, Fallopian tube, Optical scanning systems, Ovary

SPIE Journal Paper | May 24, 2016

Multispectral fluorescence imaging of human ovarian and fallopian tube tissue for early-stage cancer detection

Tate, Tyler , Baggett, Brenda , Rice, Photini F. , Koevary, Jennifer , Orsinger, Gabriel , Nymeyer, Ariel , Welge, Weston , Saboda, Kathylynn , Roe, Denise , Hatch, Kenneth , Chambers, Setsuko , Utzinger, Urs , Barton, Jennifer

JBO Vol. 21 Issue 05

KEYWORDS: Tissues, Luminescence, Fallopian tube, Multispectral imaging, Ovarian cancer, Tissue optics, Imaging systems, Cancer, Reflectivity, Data analysis

PROCEEDINGS ARTICLE | March 8, 2016

Optical coherence tomography imaging of colonic crypts in a mouse model of colorectal cancer

Proc. SPIE. 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III

KEYWORDS: Optical imaging, Endoscopy, Tissues, Optical coherence tomography, Glasses, Microscopy, Endoscopes, Colorectal cancer, Colon, In vivo imaging, Bragg cells, Mouse models

PROCEEDINGS ARTICLE | March 8, 2016

Design of an everting balloon to deploy a microendoscope to the fallopian tubes

Proc. SPIE. 9689, Photonic Therapeutics and Diagnostics XII

KEYWORDS: Safety, Tissues, Endoscopes, Fallopian tube, Uterus, Connective tissue, Prototyping, Ovarian cancer, Laparoscopy, Francium

PROCEEDINGS ARTICLE | March 8, 2016

In vivo endoscopic Doppler optical coherence tomography imaging of mouse colon

Proc. SPIE. 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III

KEYWORDS: Optical imaging, Endoscopy, Cancer, Tissues, Optical coherence tomography, Image segmentation, Endoscopes, Blood circulation, Colorectal cancer, Colon, In vivo imaging

PROCEEDINGS ARTICLE | February 29, 2016

Three-photon imaging of ovarian cancer

Proc. SPIE. 9689, Photonic Therapeutics and Diagnostics XII

KEYWORDS: Optical imaging, Second-harmonic generation, Multiphoton microscopy, Tissues, Blood, Optical coherence tomography, Luminescence, Fourier transforms, Image resolution, Collagen, Fallopian tube, Tissue optics, Ovarian cancer, Ovary

SPIE Journal Paper | September 23, 2015

In vivo molecular imaging of colorectal cancer using quantum dots targeted to vascular endothelial growth factor receptor 2 and optical coherence tomography/laser-induced fluorescence dual-modality imaging

Carbary-Ganz, Jordan , Welge, Weston , Barton, Jennifer , Utzinger, Urs

JBO Vol. 20 Issue 09

KEYWORDS: Colon, Luminescence, In vivo imaging, Tissues, Colorectal cancer, Optical coherence tomography, Tumors, Quantum dots, Bragg cells, Molecular imaging

PROCEEDINGS ARTICLE | March 13, 2015

Multispectral fluorescence imaging of human ovarian and Fallopian tube tissue for early stage cancer detection

Proc. SPIE. 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII

KEYWORDS: Tumor growth modeling, Cancer, Tissues, Imaging systems, Pathology, Luminescence, Reflectivity, Multispectral imaging, Fallopian tube, Ovarian cancer

PROCEEDINGS ARTICLE | March 2, 2015

Stray light mitigation in a novel endoscope for fallopian tubes

Proc. SPIE. 9304, Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II

KEYWORDS: Signal to noise ratio, Lenses, Reflectivity, Endoscopes, Specular reflections, Fallopian tube, Tissue optics, Stray light, Signal detection, Natural surfaces

PROCEEDINGS ARTICLE | March 2, 2015

A six-color four-laser mobile platform for multi-spectral fluorescence imaging endoscopy

Proc. SPIE. 9304, Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II

KEYWORDS: Fabry–Perot interferometers, Tissues, Ultraviolet radiation, Luminescence, Crystals, Nd:YAG lasers, Harmonic generation, Fallopian tube, Alexandrite lasers, Alexandrite

PROCEEDINGS ARTICLE | December 17, 2014

Optical design of an optical coherence tomography and multispectral fluorescence imaging endoscope to detect early stage ovarian cancer

Proc. SPIE. 9293, International Optical Design Conference 2014

KEYWORDS: Optical design, Tissues, Optical coherence tomography, Luminescence, Endoscopes, Multispectral imaging, Fallopian tube, Tissue optics, Ovarian cancer, Ovary

SPIE Journal Paper | August 6, 2014

Quantum dots targeted to vascular endothelial growth factor receptor 2 as a contrast agent for the detection of colorectal cancer

Carbary-Ganz, Jordan , Barton, Jennifer , Utzinger, Urs

JBO Vol. 19 Issue 08

KEYWORDS: Colon, Luminescence, Colorectal cancer, Quantum dots, In vivo imaging, Tissues, Tumors, Bragg cells, Receptors, Imaging systems

SPIE Journal Paper | July 18, 2014

Diagnostic potential of multimodal imaging of ovarian tissue using optical coherence tomography and second-harmonic generation microscopy

Welge, Weston , DeMarco, Andrew , Watson, Jennifer , Rice, Photini , Barton, Jennifer , Kupinski, Matthew

JMI Vol. 1 Issue 02

KEYWORDS: Optical coherence tomography, Second-harmonic generation, Tissues, Ovarian cancer, Diagnostics, Tissue optics, Ovary, Televisions, Multimodal imaging, Collagen

SPIE Journal Paper | June 3, 2014

Oblique incidence reflectometry: optical models and measurements using a side-viewing gradient index lens-based endoscopic imaging system

Wall, R. Andrew , Barton, Jennifer

JBO Vol. 19 Issue 06

KEYWORDS: Optical coherence tomography, Tissue optics, Endoscopes, Diffuse reflectance spectroscopy, Tissues, Absorption, Scattering, Colon, Reflectometry, Optical testing, Optical properties

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SPIE Journal Paper | March 27, 2014

Simultaneous multiplane imaging of human ovarian cancer by volume holographic imaging

Orsinger, Gabriel , Watson, Jennifer , Gordon, Michael , Nymeyer, Ariel , de Leon, Erich , Brownlee, Johnathan , Hatch, Kenneth , Chambers, Setsuko , Barton, Jennifer , Kostuk, Raymond , Romanowski, Marek

JBO Vol. 19 Issue 03

KEYWORDS: Tissues, Ovarian cancer, Holography, Fallopian tube, Luminescence, Holograms, Natural surfaces, Reflectivity, Ovary, Imaging systems

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PROCEEDINGS ARTICLE | March 4, 2014

Volume holographic reflection endoscope for in-vivo ovarian cancer clinical studies

Proc. SPIE. 8927, Endoscopic Microscopy IX; and Optical Techniques in Pulmonary Medicine

KEYWORDS: GRIN lenses, Holograms, Holography, Tissues, Imaging systems, Image resolution, Endoscopes, Relays, Natural surfaces, Ovarian cancer

PROCEEDINGS ARTICLE | March 4, 2014

Objective assessment of multimodality optical coherence tomography and second-harmonic generation image quality of ex vivo mouse ovaries using human observers

Proc. SPIE. 8936, Design and Quality for Biomedical Technologies VII

KEYWORDS: Second-harmonic generation, Tissues, Optical coherence tomography, Video, Diagnostics, Collagen, Televisions, Tissue optics, Ovarian cancer, Ovary

PROCEEDINGS ARTICLE | March 19, 2013

In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia

Proc. SPIE. 8577, Optical Biopsy XI

KEYWORDS: Second-harmonic generation, Multiphoton microscopy, Tumors, Visualization, Tissues, Optical coherence tomography, Luminescence, In vivo imaging, Ovary, Mouse models

PROCEEDINGS ARTICLE | March 13, 2013

Spiral-scanning, side-viewing optical coherence tomography endoscope for three-dimensional fully sampled in vivo imaging of the mouse colon

Proc. SPIE. 8575, Endoscopic Microscopy VIII

KEYWORDS: Endoscopy, Tissues, Imaging systems, Optical coherence tomography, Endoscopes, Colorectal cancer, Colon, In vivo imaging, 3D scanning, 3D image processing

PROCEEDINGS ARTICLE | March 13, 2013

Fluorescence-based SMC and OCT endoscope to study aberrant crypt foci in the mouse colon

Proc. SPIE. 8575, Endoscopic Microscopy VIII

KEYWORDS: Tumors, Visualization, Optical coherence tomography, Luminescence, Endoscopes, Colorectal cancer, Colon, In vivo imaging, Tissue optics, Bragg cells

SPIE Journal Paper | August 3, 2012

Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope

Wall, Richard , Barton, Jennifer

JBO Vol. 17 Issue 8

KEYWORDS: Optical coherence tomography, Colon, Endoscopes, GRIN lenses, Image resolution, Imaging systems, Tissues, Gradient-index optics, Prisms, Visualization

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SPIE Journal Paper | July 4, 2012

Analysis of second-harmonic-generation microscopy in a mouse model of ovarian carcinoma

Watson, Jennifer , Rice, Photini , Utzinger, Urs , Barton, Jennifer , Marion, Samuel , Hoyer, Patricia , Brewer, Molly , Davis, John , Rodríguez, Jeffrey

JBO Vol. 17 Issue 7

KEYWORDS: Ovary, Collagen, Ovarian cancer, Cancer, Diagnostics, Second-harmonic generation, Tumors, Image analysis, Microscopy, Optical fibers

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PROCEEDINGS ARTICLE | March 1, 2012

Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope

Proc. SPIE. 8217, Endoscopic Microscopy VII

KEYWORDS: GRIN lenses, Prisms, Visualization, Imaging systems, Optical coherence tomography, Image resolution, Endoscopes, Colon, Tissue optics, Neodymium

PROCEEDINGS ARTICLE | March 1, 2012

Endoscopic spectral domain optical coherence tomography of murine colonic morphology to determine effectiveness of chemopreventive and chemotherapeutic agents in colorectal cancer

Proc. SPIE. 8217, Endoscopic Microscopy VII

KEYWORDS: Gold, Endoscopy, Tissues, Optical coherence tomography, Image resolution, Image analysis, Endoscopes, Colorectal cancer, Colon, Bragg cells

SPIE Journal Paper | October 1, 2011

Ultrahigh resolution all-reflective optical coherence tomography system with a compact fiber-based supercontinuum source

Kieu, Khanh , Peyghambarian, Nasser , Klein, Justin , Barton, Jennifer , Evans, Anna

JBO Vol. 16 Issue 10

KEYWORDS: Optical coherence tomography, Fiber lasers, Light sources, Image resolution, Mirrors, Optical resolution, Reflectivity, Supercontinuum sources, Optical components, Laser sources

PROCEEDINGS ARTICLE | September 21, 2011

Volume holographic spectral-spatial imaging of biological tissue

Proc. SPIE. 8122, Tribute to Joseph W. Goodman

KEYWORDS: Diffraction, Holograms, Holography, Tissues, Imaging systems, Wavefronts, Multiplexing, Tissue optics, Volume holography, Diffraction gratings

SPIE Journal Paper | June 1, 2011

Design of a handheld optical coherence microscopy endoscope

Korde, Vrushali , Barton, Jennifer , Liebmann, Erica

JBO Vol. 16 Issue 06

KEYWORDS: Endoscopes, Ovary, Tissue optics, Tissues, Tolerancing, Optical coherence microscopy, Mirrors, Relays, Objectives, Optical coherence tomography

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PROCEEDINGS ARTICLE | February 22, 2011

Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model

Proc. SPIE. 7890, Advanced Biomedical and Clinical Diagnostic Systems IX

KEYWORDS: Optical imaging, Microscopes, Second-harmonic generation, Cancer, Tissues, Optical coherence tomography, In vivo imaging, Ovarian cancer, Ovary, Mouse models

PROCEEDINGS ARTICLE | February 8, 2011

Spatial-spectral 3D imaging system using broadband sources

Proc. SPIE. 7904, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XVIII

KEYWORDS: Diffraction, Holograms, Holography, Imaging systems, Cameras, Stereoscopy, Objectives, Volume holography, Fiber optic illuminators, Diffraction gratings

SPIE Journal Paper | July 1, 2010

Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon

Winkler, Amy , Rice, Photini , Drezek, Rebekah , Barton, Jennifer

JBO Vol. 15 Issue 04

KEYWORDS: Optical coherence tomography, Colon, Tissues, Signal attenuation, Bragg cells, Scattering, Gold, Natural surfaces, In vivo imaging, Image segmentation

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SPIE Journal Paper | April 1, 2010

Optical design for a spatial-spectral volume holographic imaging system

Gelsinger-Austin, Paul , Luo, Yuan , Watson, Jonathan , Kostuk, Raymond , Barbastathis, George , Barton, Jennifer , Castro, Jose

OE Vol. 49 Issue 04

KEYWORDS: Holograms, Holography, Optical design, Imaging systems, Objectives, Relays, Confocal microscopy, Microscopes, Optical engineering, Lenses

PROCEEDINGS ARTICLE | February 26, 2010

New scheme for polarimetric glucose sensing without polarizers

Proc. SPIE. 7572, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics

KEYWORDS: Eye, Glucose, Cornea, Modulation, Polarization, Birefringence, Blood, Polarizers, Wave plates, Polarimetry

PROCEEDINGS ARTICLE | February 24, 2010

Focused OCT and LIF endoscope

Proc. SPIE. 7558, Endoscopic Microscopy V

KEYWORDS: Imaging systems, Optical coherence tomography, Reflectivity, Image resolution, Laser induced fluorescence, Endoscopes, Colorectal cancer, Epoxies, Colon, In vivo imaging

SPIE Journal Paper | January 1, 2010

Application of optical coherence tomography to automated contact lens metrology

Davidson, Bryan , Barton, Jennifer

JBO Vol. 15 Issue 01

KEYWORDS: Optical coherence tomography, Contact lenses, Image segmentation, Prisms, Glasses, Metrology, Refraction, Microscopes, Algorithm development, Image processing algorithms and systems

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PROCEEDINGS ARTICLE | March 3, 2009

Design of a handheld optical coherence microscopy endoscope

Proc. SPIE. 7172, Endoscopic Microscopy IV

KEYWORDS: Mirrors, Tissues, Lenses, Optical coherence tomography, Image resolution, Endoscopes, Objectives, Relays, Modulation transfer functions, Optical coherence microscopy

PROCEEDINGS ARTICLE | February 24, 2009

Automated contact lens measurement using optical coherence tomography

Proc. SPIE. 7169, Advanced Biomedical and Clinical Diagnostic Systems VII

KEYWORDS: Microscopes, Prisms, Metrology, Optical coherence tomography, Image segmentation, Glasses, Nondestructive evaluation, Refraction, Contact lenses, Algorithm development

PROCEEDINGS ARTICLE | February 23, 2009

Laparoscopic optical coherence tomographic imaging of human ovarian cancer

Proc. SPIE. 7169, Advanced Biomedical and Clinical Diagnostic Systems VII

KEYWORDS: Coherence imaging, Coherence (optics), Visualization, Tissues, Optical coherence tomography, Glasses, Collagen, Ovarian cancer, Ovary, Laparoscopy

PROCEEDINGS ARTICLE | February 21, 2009

In vivo imaging using a VEGF-based near-infrared fluorescent probe for early cancer diagnosis in the AOM-treated mouse model

Proc. SPIE. 7190, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications

KEYWORDS: Cancer, Tumors, Optical coherence tomography, Luminescence, Laser induced fluorescence, Colorectal cancer, Receptors, Colon, In vivo imaging, Mouse models

SPIE Journal Paper | January 1, 2009

Lab Building 101

Barton, Jennifer

MGSP Vol. 4 Issue 01

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SPIE Journal Paper | July 1, 2008

Fiber array fabrication technique for 15-µm-diameter single-mode fibers

Arauz, Lina , Luo, Yuan , Castillo, Jose , Barton, Jennifer , Kostuk, Raymond

OE Vol. 47 Issue 07

SPIE Journal Paper | March 1, 2008

Use of hyperosmotic chemical agent to improve the laser treatment of cutaneous vascular lesions

Vargas, Gracie , Barton, Jennifer , Welch, Ashley

JBO Vol. 13 Issue 02

KEYWORDS: Skin, Blood vessels, Laser coagulation, Tissue optics, Doppler effect, Laser irradiation, Tissues, Blood circulation, Laser therapeutics, Signal attenuation

PROCEEDINGS ARTICLE | February 21, 2008

Laparoscopic optical coherence tomographic imaging of human ovarian cancer

Proc. SPIE. 6851, Endoscopic Microscopy III

KEYWORDS: Coherence imaging, Coherence (optics), Tissues, Optical coherence tomography, Image resolution, Collagen, In vivo imaging, Ovarian cancer, Ovary, Laparoscopy

PROCEEDINGS ARTICLE | February 21, 2008

Scatter sensitive microscopic techniques to identify contrasting mucosal structures in ultrahigh-resolution optical coherence tomograms of mouse colon

Proc. SPIE. 6851, Endoscopic Microscopy III

KEYWORDS: Confocal microscopy, Coherence (optics), Tissues, Scattering, Optical coherence tomography, Microscopy, Reflectivity, Colon, Tissue optics, Natural surfaces

PROCEEDINGS ARTICLE | February 21, 2008

Fluorescent and scattering contrast agents in a mouse model of colorectal cancer

Proc. SPIE. 6851, Endoscopic Microscopy III

KEYWORDS: Tissues, Scattering, Nanoparticles, Optical coherence tomography, Laser induced fluorescence, Endoscopes, Colorectal cancer, Colon, In vivo imaging, Nanorods

PROCEEDINGS ARTICLE | February 15, 2008

Imaging stented tissue engineered blood vessel mimics

Proc. SPIE. 6858, Optics in Tissue Engineering and Regenerative Medicine II

KEYWORDS: Visualization, Tissues, Imaging systems, Blood vessels, Optical coherence tomography, Metals, Arteries, Endoscopes, Software development, Tissue optics

PROCEEDINGS ARTICLE | January 26, 2008

Multiplexing volume holographic gratings for a spectral-spatial imaging system

Proc. SPIE. 6912, Practical Holography XXII: Materials and Applications

KEYWORDS: Optical filters, Holograms, Holography, 3D image reconstruction, Imaging systems, Multiplexing, Image filtering, Volume holography, Spherical lenses, Diffraction gratings

PROCEEDINGS ARTICLE | July 13, 2007

Automatic segmentation of cell nuclei in bladder and skin tissue for karyometric analysis

Proc. SPIE. 6633, Biophotonics 2007: Optics in Life Science

KEYWORDS: Statistical analysis, Cancer, Tissues, Image segmentation, Digital filtering, Skin, Skin cancer, Image filtering, Absorbance, Bladder

PROCEEDINGS ARTICLE | July 11, 2007

Simultaneous optical coherence and multiphoton microscopy of skin-equivalent tissue models

Proc. SPIE. 6627, Optical Coherence Tomography and Coherence Techniques III

KEYWORDS: Second-harmonic generation, Multiphoton microscopy, Coherence (optics), Optical coherence tomography, Skin, Microscopy, Luminescence, Collagen, Tissue optics, Rhodamine

SPIE Journal Paper | March 1, 2007

Assessment of blood vessel mimics with optical coherence tomography

Bonnema, Garret , Cardinal, Kristen , McNally, James , Williams, Stuart , Barton, Jennifer

JBO Vol. 12 Issue 02

KEYWORDS: Optical coherence tomography, Endoscopes, Visualization, Blood vessels, Tissues, Endoscopy, Imaging systems, Metals, Arteries, Tissue optics

PROCEEDINGS ARTICLE | February 13, 2007

Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography

Proc. SPIE. 6432, Endoscopic Microscopy II

KEYWORDS: Endoscopy, Visualization, Tissues, Signal attenuation, Optical coherence tomography, Endoscopes, Colon, Bragg cells, Error control coding, Mouse models

PROCEEDINGS ARTICLE | February 7, 2007

Inherent media dispersion compensation by FD-OCT

Proc. SPIE. 6429, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI

KEYWORDS: Point spread functions, Imaging systems, Spatial frequencies, Interferometers, Dispersion, Optical coherence tomography, Water, Spectroscopy, Transform theory, Refraction

PROCEEDINGS ARTICLE | February 7, 2007

10-channel fiber array fabrication technique for a parallel optical coherence tomography system

Proc. SPIE. 6429, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI

KEYWORDS: Endoscopy, Silica, Interferometers, Cladding, Optical coherence tomography, Etching, Glasses, Silicon, Single mode fibers, Tissue optics

SPIE Journal Paper | November 1, 2006

In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope

Tumlinson, Alexandre , Považay, Boris , Hariri, Lida , McNally, James , Unterhuber, Angelika , Hermann, Boris , Sattmann, Harald , Drexler, Wolfgang , Barton, Jennifer

JBO Vol. 11 Issue 06

KEYWORDS: Endoscopes, Optical coherence tomography, Colon, In vivo imaging, Tissues, Mirrors, Endoscopy, GRIN lenses, Imaging systems, Reflection

SPIE Journal Paper | July 1, 2006

Dual modality imaging of a novel rat model of ovarian carcinogenesis

Kanter, Elizabeth , Walker, Ross , Marion, Sam , Brewer, Molly , Hoyer, Patricia , Barton, Jennifer

JBO Vol. 11 Issue 04

KEYWORDS: Ovary, Optical coherence tomography, Laser induced fluorescence, Ovarian cancer, Cancer, Luminescence, Control systems, Tumor growth modeling, Tissues, Animal model studies

SPIE Journal Paper | July 1, 2006

Quantitative evaluation of optical coherence tomography signal enhancement with gold nanoshells

Agrawal, Anant , Huang, Stanley , Lin, Alex , Lee, Min-Ho , Barton, Jennifer , Drezek, Rebekah , Pfefer, Joshua

JBO Vol. 11 Issue 04

KEYWORDS: Optical coherence tomography, Signal attenuation, Gold, Backscatter, Tissues, Scattering, Tumors, Particles, Optical properties, Signal detection

PROCEEDINGS ARTICLE | October 7, 2005

An achromatized endoscope for ultrahigh-resolution optical coherence tomography

Proc. SPIE. 5861, Optical Coherence Tomography and Coherence Techniques II

KEYWORDS: Endoscopy, GRIN lenses, Mirrors, Tissues, Optical coherence tomography, Lens design, Endoscopes, Colon, In vivo imaging, Tissue optics

PROCEEDINGS ARTICLE | October 7, 2005

Optical coherence tomography imaging and fluorescence spectroscopy of a novel rat model of ovarian cancer

Proc. SPIE. 5861, Optical Coherence Tomography and Coherence Techniques II

KEYWORDS: Coherence imaging, Tumor growth modeling, Tissues, Optical coherence tomography, Luminescence, Imaging spectroscopy, Laser induced fluorescence, Ovarian cancer, Ovary, Animal model studies

PROCEEDINGS ARTICLE | April 25, 2005

Use of multiple imaging modalities to detect ovarian cancer

Proc. SPIE. 5686, Photonic Therapeutics and Diagnostics

KEYWORDS: Tumor growth modeling, Cancer, Visualization, Tissues, Optical coherence tomography, Luminescence, Laser induced fluorescence, Ovarian cancer, Ovary, Animal model studies

PROCEEDINGS ARTICLE | April 13, 2005

Flow measurement using speckle in optical coherence tomography images

Proc. SPIE. 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX

KEYWORDS: Doppler effect, Tissues, Imaging systems, Speckle, Optical coherence tomography, Image processing, Speckle analysis, Speckle pattern, Signal detection, Doppler tomography

PROCEEDINGS ARTICLE | April 1, 2005

Endoscopic ultrahigh-resolution OCT for in vivo imaging colon disease model mice

Proc. SPIE. 5692, Advanced Biomedical and Clinical Diagnostic Systems III

KEYWORDS: Endoscopy, GRIN lenses, Mirrors, Tissues, Optical coherence tomography, Lens design, Endoscopes, Colon, In vivo imaging, Tissue optics

PROCEEDINGS ARTICLE | April 1, 2005

Ex vivo optical coherence tomography and laser induced fluorescence spectroscopy imaging of murine gastrointestinal tract

Proc. SPIE. 5692, Advanced Biomedical and Clinical Diagnostic Systems III

KEYWORDS: Tissues, Optical coherence tomography, Control systems, Laser induced fluorescence, Colorectal cancer, Colon, Intestine, Bragg cells, Esophagus, Mouse models

PROCEEDINGS ARTICLE | April 1, 2005

A low-cost customized analog circuit design for optical coherence microscopy

Proc. SPIE. 5692, Advanced Biomedical and Clinical Diagnostic Systems III

KEYWORDS: Optical amplifiers, Biomedical optics, Optical coherence tomography, Amplifiers, Linear filtering, Demodulation, In vivo imaging, Analog electronics, Optical coherence microscopy, Phase shifts

PROCEEDINGS ARTICLE | December 29, 2004

Nanoshells for integrated diagnosis and therapy of cancer

Proc. SPIE. 5593, Nanosensing: Materials and Devices

KEYWORDS: Gold, Near infrared, Biomedical optics, Cancer, Tumors, Scattering, Nanoparticles, Optical coherence tomography, Tissue optics, Absorption

PROCEEDINGS ARTICLE | July 1, 2004

Nanoshells as an optical coherence tomography contrast agent

Proc. SPIE. 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII

KEYWORDS: Gold, Near infrared, Tissues, Scattering, Signal attenuation, Nanoparticles, Optical coherence tomography, Skin, In vivo imaging, In vitro testing

PROCEEDINGS ARTICLE | July 1, 2004

Texture analysis of speckle in optical coherence tomography images of tissue phantoms

Proc. SPIE. 5318, Advanced Biomedical and Clinical Diagnostic Systems II

KEYWORDS: Statistical analysis, Tissues, Imaging systems, Speckle, Optical coherence tomography, Image resolution, Image analysis, Collagen, Speckle pattern, Tissue optics

SPIE Journal Paper | May 1, 2004

Dual modality instrument for simultaneous optical coherence tomography imaging and fluorescence spectroscopy

Barton, Jennifer , Guzman, Francisco , Tumlinson, Alexandre

JBO Vol. 9 Issue 03

KEYWORDS: Optical coherence tomography, Laser induced fluorescence, Tissues, Luminescence, Imaging spectroscopy, Tissue optics, Fluorescence spectroscopy, Coherence imaging, Beam splitters, Absorption

PROCEEDINGS ARTICLE | July 22, 2003

Texture analysis for tissue classification of optical coherence tomography images

Proc. SPIE. 4958, Advanced Biomedical and Clinical Diagnostic Systems

KEYWORDS: Eye, Statistical analysis, Tissues, Speckle, Optical coherence tomography, Image analysis, Lung, Speckle pattern, Image classification, Tissue optics

PROCEEDINGS ARTICLE | July 8, 2003

Miniature endoscope for a combined OCT-LIF system

Proc. SPIE. 4956, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII

KEYWORDS: GRIN lenses, Prisms, Silica, Tissues, Optical coherence tomography, Luminescence, Laser induced fluorescence, Endoscopes, Colon, Tissue optics

SPIE Journal Paper | July 1, 2003

Texture analysis of optical coherence tomography images: feasibility for tissue classification

Gossage, Kirk , Tkaczyk, Tomasz , Rodriguez, Jeffrey , Barton, Jennifer

JBO Vol. 8 Issue 03

KEYWORDS: Tissues, Optical coherence tomography, Lung, Speckle, Image classification, Skin, Tissue optics, Statistical analysis, Eye, Ultrasonography

PROCEEDINGS ARTICLE | June 17, 2002

Catheter-based instrument for simultaneous OCT imaging and fluorescence spectroscopy

Proc. SPIE. 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII

KEYWORDS: Optical fibers, Tissues, Optical coherence tomography, Luminescence, Fluorescence spectroscopy, Imaging spectroscopy, Arteries, Laser induced fluorescence, Laser tissue interaction, Absorption

PROCEEDINGS ARTICLE | June 17, 2002

Optical and magnetic resonance changes in photothermally coagulating blood

Proc. SPIE. 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII

KEYWORDS: Scattering, Blood, Optical coherence tomography, Magnetic resonance imaging, Molecules, Laser scattering, Reflectivity, Integrating spheres, Pulsed laser operation, Absorption

PROCEEDINGS ARTICLE | June 14, 2002

Speckle image properties in optical coherence tomography

Proc. SPIE. 4619, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI

KEYWORDS: Statistical analysis, Optical spheres, Tissues, Imaging systems, Speckle, Scattering, Optical coherence tomography, Surface roughness, Speckle pattern, Biological research

PROCEEDINGS ARTICLE | June 13, 2002

Using optical coherence tomography to evaluate glaucoma implant healing response in rabbit eyes

Proc. SPIE. 4611, Ophthalmic Technologies XII

KEYWORDS: Eye, Visualization, Tissues, Surgery, Imaging systems, Optical coherence tomography, Sclera, Imaging devices, In vivo imaging, Tissue optics

SPIE Journal Paper | January 1, 2002

Real-time in vivo color Doppler optical coherence tomography

Rollins, Andrew , Yazdanfar, Siavash , Barton, Jennifer , Izatt, Joseph

JBO Vol. 7 Issue 01

KEYWORDS: Doppler effect, Optical coherence tomography, Imaging systems, Real time imaging, In vivo imaging, Digital signal processing, Blood circulation, Doppler tomography, Signal processing, Tissues

PROCEEDINGS ARTICLE | July 9, 2001

Time-domain optical and thermal properties of blood undergoing laser photocoagulation

Proc. SPIE. 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Refractive index, Laser coagulation, Optical properties, Scattering, Blood, Reflectivity, Laser beam diagnostics, Pulsed laser operation, Thermal modeling, Absorption

We have examined the temporal characteristics of the optical properties of blood undergoing laser-induced photocoagulation during long pulse (10 ms) 532-nm irradiation. The time-domain optical properties were probed at 532 nm, 594 nm, 633 nm and 1064 nm using a newly developed pump-probe technique in a double integrating sphere apparatus. During the 10 ms illumination period, blood evolves from liquid to a liquid blood-coagulum mixture to a system at the liquid/vapor transition in an essentially adiabatic manner. As with previous studies, a sharp rise in the 532 nm signal remitted from the sample can be linked to the onset of coagulation and a concomitant increase in scattering caused by microscopic coagulum particles. We also observe a subsequent decay in this remittance and, at sufficiently high radiant exposures, acoustic and visual transients indicating the onset of microvaporization. Probing the sample at the other wavelengths, we show that the optical properties of the system display highly complex behavior in multiple time frames. We believe that this rich behavior results from the interplay of: i) a time/temperature-dependent red-shift in the absorption spectrum of the oxy-hemoglobin chromophore, ii) coagulation dynamics occurring on at least two distinct time and length scales, and, iii) the creation of at least one new chemical species possessing a different absorption spectrum to that of oxy-hemoglobin. The thermal properties of the system were measured in a time- and spatially-resolved manner using a newly developed technique, and modeled using finite-element analysis incorporating the effects of time-dependent changes in the absorption coefficients of the blood, and phase changes representing coagulation and the liquid/vapor transition. Cross-correlating the optical and thermal studies, we show that the temporal properties of the 532 nm and 633 nm remittance signals can potentially be used to develop a sensitive real-time probe of the onset of coagulation, which in turn will lead to accurate dosimetry during clinical procedures. We also show that the three features of the coagulation highlighted above have profound implications for the design of lasers for vascular therapeutic applications.

PROCEEDINGS ARTICLE | May 23, 2001

Optical-thermal model verification by high-speed optical coherence tomography

Proc. SPIE. 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V

KEYWORDS: Tissues, Blood, Blood vessels, Optical coherence tomography, Skin, Laser irradiation, In vivo imaging, Tissue optics, Pulsed laser operation, Laser tissue interaction

PROCEEDINGS ARTICLE | May 21, 2001

Dual OCT/spectroscopy system for identification of vascular pathology

Proc. SPIE. 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI

KEYWORDS: Mirrors, Tissues, Optical coherence tomography, Pathology, Spectroscopy, Luminescence, Imaging spectroscopy, Laser induced fluorescence, System identification, Tissue optics

PROCEEDINGS ARTICLE | May 21, 2001

Cooperative phenomena in two-pulse two-color laser photocoagulation of cutaneous blood vessels

Proc. SPIE. 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI

KEYWORDS: Optical spheres, Scattering, Signal attenuation, Blood, Blood vessels, Skin, Laser scattering, In vivo imaging, In vitro testing, Absorption

PROCEEDINGS ARTICLE | June 13, 2000

Optical coherence tomography imaging of collagenous tissue microstructure

Proc. SPIE. 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical

KEYWORDS: Optical imaging, Coherence imaging, Birefringence, Visualization, Tissues, Optical coherence tomography, Nondestructive evaluation, Collagen, Distance measurement, Tissue optics

PROCEEDINGS ARTICLE | May 17, 2000

Selective photocoagulation of cutaneous blood vessels: evaluation of vessel damage by color Doppler optical coherence tomography

Proc. SPIE. 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X

KEYWORDS: Doppler effect, Visualization, Imaging systems, Blood, Blood vessels, Optical coherence tomography, Video, Skin, Blood circulation, Doppler tomography

PROCEEDINGS ARTICLE | April 28, 2000

Imaging vascular implants with optical coherence tomography

Proc. SPIE. 3915, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV

KEYWORDS: GRIN lenses, Tissues, Imaging systems, Blood, Blood vessels, Optical coherence tomography, Polymers, Arteries, Intravascular ultrasound, In vitro testing

PROCEEDINGS ARTICLE | April 30, 1999

Assessing vessel damage with color Doppler optical coherence tomography following irradiations with cooling

Proc. SPIE. 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III

KEYWORDS: Ferroelectric materials, Blood vessels, Optical coherence tomography, Skin, Laser irradiation, Blood circulation, Pulsed laser operation, Doppler tomography, Cryogenics, Temperature metrology

PROCEEDINGS ARTICLE | July 1, 1998

Laser treatment of port wine stains: three-dimensional simulation using biopsy-defined geometry in an optical-thermal model

Proc. SPIE. 3245, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII

KEYWORDS: Laser therapeutics, Tissues, Blood, Blood vessels, Skin, 3D modeling, Monte Carlo methods, Optical simulations, Tissue optics, Thermal modeling

PROCEEDINGS ARTICLE | July 1, 1998

Infrared imaging of CO2 laser ablation: implications for laser skin resurfacing

Proc. SPIE. 3245, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII

KEYWORDS: Tissues, Cameras, Skin, Carbon dioxide lasers, Combustion, Laser ablation, In vivo imaging, Natural surfaces, Laser tissue interaction, Temperature metrology

PROCEEDINGS ARTICLE | April 24, 1998

Investigating laser/blood-vessel interaction with color Doppler optical coherence tomography

Proc. SPIE. 3251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II

KEYWORDS: Ferroelectric materials, Doppler effect, Blood, Blood vessels, Skin, Photography, Laser irradiation, Blood circulation, Pulsed laser operation, Doppler tomography

PROCEEDINGS ARTICLE | April 24, 1998

Diagnostic blood-flow monitoring during therapeutic interventions using color Doppler optical coherence tomography

Proc. SPIE. 3251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II

KEYWORDS: Endoscopy, Visualization, Tissues, Blood vessels, Optical coherence tomography, Skin, Diagnostics, Blood circulation, Tissue optics, Doppler tomography

PROCEEDINGS ARTICLE | June 16, 1997

Adaptable three-dimensional Monte Carlo modeling of imaged blood vessels in skin

Proc. SPIE. 2975, Laser-Tissue Interaction VIII

KEYWORDS: Data modeling, Tissues, Blood vessels, Skin, 3D modeling, Monte Carlo methods, Optical simulations, Tissue optics, Photon transport, Absorption

PROCEEDINGS ARTICLE | May 22, 1997

Three-dimensional reconstruction of rat dermal blood vessels in vivo

Proc. SPIE. 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII

KEYWORDS: 3D image reconstruction, Doppler effect, Tissues, Blood, Blood vessels, Optical coherence tomography, Image processing, Skin, Image analysis, In vivo imaging

PROCEEDINGS ARTICLE | May 22, 1997

Infrared imaging of CO2 laser resurfacing

Proc. SPIE. 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII

KEYWORDS: Infrared imaging, Tissues, Cameras, Skin, Carbon dioxide lasers, Laser ablation, Picosecond phenomena, Pulsed laser operation, Laser tissue interaction, Temperature metrology

SPIE Journal Paper | April 2, 1997

Optical low-coherence reflectometry to enhance monte Carlo modeling of skin

Barton, Jennifer , Milner, Thomas , Pfefer, T. Joshua , Nelson, J. Stuart , Welch, Ashley

JBO Vol. 2 Issue 02

KEYWORDS: Blood vessels, Skin, Tissues, Monte Carlo methods, Confocal microscopy, Blood, Reflectometry, Photons, Tissue optics, Doppler effect

PROCEEDINGS ARTICLE | May 7, 1996

Wavelength dependency of soft tissue coagulation with a tunable cw laser

Proc. SPIE. 2681, Laser-Tissue Interaction VII

KEYWORDS: Breast, Tunable lasers, Continuous wave operation, Liver, Cornea, Tissues, Cameras, Laser tissue interaction, Temperature metrology, Absorption

Showing 5 of 100 publications

Conference Committee Involvement (15)

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV

14 February 2016 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII

8 February 2015 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII

2 February 2014 | San Francisco, California, United States

Optical Coherence Tomography and Coherence Techniques VI

13 May 2013 | Munich, Germany

Advanced Biomedical and Clinical Diagnostic Systems X

22 January 2012 | San Francisco, California, United States

Showing 5 of 15 published special sections

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